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PubMed Publications| Keyword search (4,163 papers available) |  |
"Dagher A" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | Farahani A; Liu ZQ; Ceballos EG; Hansen JY; Wennberg K; Zeighami Y; Dadar M; Gauthier CJ; Dagher A; Misic B; | 40729400 PHYSICS |
| 2 | A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography | Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M; | 39725679 CSBN |
| 3 | A dataset of multi-contrast unbiased average MRI templates of a Parkinson's disease population | Madge V; Fonov VS; Xiao Y; Zou L; Jackson C; Postuma RB; Dagher A; Fon EA; Collins DL; | 37213552 IMAGING |
| 4 | Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain | Hansen JY; Markello RD; Tuominen L; Nørgaard M; Kuzmin E; Palomero-Gallagher N; Dagher A; Misic B; | 36209794 CSBN |
| 5 | Normal cognition in Parkinson's disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [(18)F]-FEOBV | Legault-Denis C; Aghourian M; Soucy JP; Rosa-Neto P; Dagher A; Aumont E; Wickens R; Bedard MA; | 34628195 PERFORM |
| 6 | Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion | D' Amour-Horvat V; Cox SML; Dagher A; Kolivakis T; Jaworska N; Leyton M; | 34463411 CSBN |
| 7 | mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use. | Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M | 32413893 CSBN |
| 8 | Extra-striatal D2/3 receptor availability in youth at risk for addiction. | Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M | 32259831 CSBN |
| 9 | Cocaine cue-induced dopamine release in the human prefrontal cortex. | Milella MS, Fotros A, Gravel P, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Reader AJ, Dagher A, Benkelfat C, Leyton M | 26900792 CSBN |
| 10 | Cyberinfrastructure for Open Science at the Montreal Neurological Institute. | Das S, Glatard T, Rogers C, Saigle J, Paiva S, MacIntyre L, Safi-Harab M, Rousseau ME, Stirling J, Khalili-Mahani N, MacFarlane D, Kostopoulos P, Rioux P, Madjar C, Lecours-Boucher X, Vanamala S, Adalat R, Mohaddes Z, Fonov VS, Milot S, Leppert I, Degroot C, Durcan TM, Campbell T, Moreau J, Dagher A, Collins DL, Karamchandani J, Bar-Or A, Fon EA, Hoge R, Baillet S, Rouleau G, Evans AC | 28111547 IMAGING |
| 11 | Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers. | Booij L, Welfeld K, Leyton M, Dagher A, Boileau I, Sibon I, Baker GB, Diksic M, Soucy JP, Pruessner JC, Cawley-Fiset E, Casey KF, Benkelfat C | 26905412 PSYCHOLOGY |
| Title: | Normal cognition in Parkinson's disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [(18)F]-FEOBV | ||||
| Authors: | Legault-Denis C, Aghourian M, Soucy JP, Rosa-Neto P, Dagher A, Aumont E, Wickens R, Bedard MA | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34628195/ | ||||
| DOI: | 10.1016/j.parkreldis.2021.09.018 | ||||
| Publication: | Parkinsonism & related disorders | ||||
| Keywords: | Acetylcholine; Cognition; FEOBV; Mild cognitive impairment; PET imaging; | ||||
| PMID: | 34628195 | Category: | Date Added: | 2021-10-12 | |
| Dept Affiliation: |
PERFORM
1 NeuroQAM Research Centre, Université du Québec à Montréal (UQAM), Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada. 2 McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada; PERFORM Research Centre, Concordia University, Canada. 3 McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada; McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Canada. 4 McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada. 5 NeuroQAM Research Centre, Université du Québec à Montréal (UQAM), Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada; McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Canada. Electronic address: bedard.marc-andre@uqam.ca. |
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Description: |
Background: Severe cholinergic degeneration is known to occur in Parkinson's disease (PD) and is thought to play a primary role in the cognitive decline associated with this disease. Although cholinergic losses occur in all patients with PD, cognitive performance remains normal for many of them, suggesting compensatory mechanisms in those. Objectives: This exploratory study aimed at verifying if normal cognition in PD may involve distinctive features of the brain cholinergic systems. Methods: Following extensive neuropsychological screening in 25 patients with PD, 12 were selected and evenly distributed between a cognitively normal (PD-CN) group, and a mild cognitive impairment (PD-MCI) group. Each group was compared with matched healthy volunteers (HV) on standardized cognitive scales (MoCA, PDCRS), and PET imaging with [18F]-FEOBV, a sensitive measurement of brain cholinergic innervation density. Results: [18F]-FEOBV uptake reductions were observed in PD-CN as well as in PD-MCI, with the lowest values located in the posterior cortical areas. However, in PD-CN but not in PD-MCI, there was a significant and bilateral increase of [18F]-FEOBV uptake, exclusively located in the hippocampus. Significant correlations were observed between cognitive performance and hippocampal [18F]-FEOBV uptake. Conclusion: These findings suggest a compensatory upregulation of the hippocampal cholinergic innervation in PD-CN, which might underly normal cognitive performances in spite of cortical cholinergic denervation in other regions. |
