Keyword search (4,164 papers available)

"D'Cunha TM" Authored Publications:

Title Authors PubMed ID
1 A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction. D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U 31811350
PSYCHOLOGY
2 Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones. Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U 26246318
CSBN
3 Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core. D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U 27824052
CSBN

 

Title:A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.
Authors:D'Cunha TM,  Chisholm A,  Hryhorczuk C,  Fulton S,  Shalev U
Link:https://www.ncbi.nlm.nih.gov/pubmed/31811350
DOI:10.1007/s00213-019-05415-9
Publication:Psychopharmacology
Keywords:Food restriction;  Ghrelin;  Heroin;  Leptin;  Self-administration;  Ventral tegmental area; 
PMID:31811350 Category:Psychopharmacology (Berl) Date Added:2019-12-08
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montreal, Quebec, Canada.
2 Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada.
3 Centre de Recherche du CHUM, Montreal Diabetes Research Centre, Université de Montréal, Quebec, Canada.
4 Department of Psychology, Concordia University, Montreal, Quebec, Canada. uri.shalev@concordia.ca.
5 Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada. uri.shalev@concordia.ca.

Description:

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors.

OBJECTIVES: We investigated the role of leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

METHODS: Rats self-administered heroin (0.1 mg/kg/infusion) for 10 days followed by 14 days of drug withdrawal. During withdrawal, rats were food restricted to 90% of their original body weight or were given free access to food. In experiment 1, we measured the plasma concentrations of leptin and ghrelin following heroin self-administration and withdrawal. In experiment 2, leptin was administered centrally (2.0 or 4.0 µg; i.c.v.) prior to a heroin-seeking test under extinction conditions. High density of both leptin and ghrelin receptors was previously identified in the ventral tegmental area (VTA), suggesting a direct effect on reward and motivation. Hence, we administered leptin (experiment 3; 0.125 or 0.250 µg/side), or ghrelin receptor antagonist JMV 2959 (experiment 4; 2.0 or 10.0 µg/side) directly into the VTA prior to the heroin-seeking test.

RESULTS: Chronic food restriction significantly decreased plasma levels of leptin and elevated plasma levels of ghrelin. Central administration of leptin had no statistically significant effect on heroin seeking. Intra-VTA administration of either leptin or JMV 2959 dose-dependently and selectively decreased heroin seeking in the food-restricted rats.

CONCLUSIONS: Leptin and ghrelin transmission in the VTA can modulate the augmentation of heroin seeking induced by chronic food restriction.

PMID: 31811350 [PubMed - indexed for MEDLINE]




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