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PubMed Publications| Keyword search (4,163 papers available) |  |
"Cote S" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults | Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H; | 40646404 PERFORM |
| 2 | Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences | Bouliane M; Boivin M; Kretschmer T; Lafreniere B; Paquin S; Tremblay R; Côté S; Gouin JP; Andlauer TFM; Petitclerc A; Ouellet-Morin I; | 39907790 PSYCHOLOGY |
| 3 | A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography | Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M; | 39725679 CSBN |
| 4 | All together now: Assessing variation in maternal and nonmaternal handling of wild Colobus vellerosus infants | King AG; Rissling T; Cote S; Sicotte P; | 38654439 BIOLOGY |
| 5 | Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis | Mascheretti S; Forni D; Lampis V; Fumagalli L; Paquin S; Andlauer TFM; Wang W; Dionne G; Brendgen MR; Vitaro F; Ouellet-Morin I; Rouleau G; Gouin JP; Côté S; Tremblay RE; Turecki G; Garon-Carrier G; Boivin M; Battaglia M; | 37146008 PSYCHOLOGY |
| 6 | Depression, anxiety, and suicidal ideation in a population-based cohort of young adults before and during the first 12 months of the COVID-19 pandemic in Canada | Gouin JP; MacNeil S; de la Torre-Luque A; Chartrand E; Chadi N; Rouquette A; Boivin M; Côté S; Geoffroy MC; | 37093498 PSYCHOLOGY |
| 7 | Association of Childhood Externalizing, Internalizing, and Comorbid Symptoms With Long-term Economic and Social Outcomes | Vergunst F; Commisso M; Geoffroy MC; Temcheff C; Poirier M; Park J; Vitaro F; Tremblay R; Côté S; Orri M; | 36622675 PSYCHOLOGY |
| 8 | Pathways of association between disordered eating in adolescence and mental health outcomes in young adulthood during the COVID-19 pandemic | Loose T; Geoffroy MC; Orri M; Chadi N; Scardera S; Booij L; Breton E; Tremblay R; Boivin M; Coté S; | 36482144 PSYCHOLOGY |
| 9 | Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort | Watkins-Martin K; Orri M; Pennestri MH; Castellanos-Ryan N; Larose S; Gouin JP; Ouellet-Morin I; Chadi N; Philippe F; Boivin M; Tremblay RE; Côté S; Geoffroy MC; | 34496901 PSYCHOLOGY |
| 10 | mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use. | Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M | 32413893 CSBN |
| Title: | Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults | ||||
| Authors: | Ferland MC, Wang R, Therrien-Blanchet JM, Remahi S, Côté S, Fréchette AJ, Dang-Vu TT, Liu H, Lepage JF, Théoret H | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40646404/ | ||||
| DOI: | 10.1007/s11682-025-01043-4 | ||||
| Publication: | Brain imaging and behavior | ||||
| Keywords: | Benzodiazepine; Functional connectivity; Lorazepam; Resting state; fMRI; | ||||
| PMID: | 40646404 | Category: | Date Added: | 2025-07-12 | |
| Dept Affiliation: |
PERFORM
1 Department of Psychology, Faculté des Arts et Sciences, Université de Montréal, Montréal, Canada. 2 Changping Laboratory & Peking University, Beijing, China. 3 Department of Pediatrics, Faculty of Medicine and Health Sciences, Université Sherbrooke Hospital Research Center, Sherbrooke, Canada. 4 Center for Studies in Behavioral Neurobiology and Perform Center, Department of Health, Kinesiology and Applied Physiology, Concordia University, Montréal, Canada. 5 Research Center, Institut Universitaire de Gériatrie de Montréal, Montréal, Canada. 6 Department of Psychology, Faculté des Arts et Sciences, Université de Montréal, Montréal, Canada. hugo.theoret@umontreal.ca. |
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Description: |
Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effects of a single dose of lorazepam on brain functional connectivity at rest is not known. In this placebo-controlled, crossover study, twenty healthy adult participants (9 women; 26.2 ± 5.2 years) underwent two resting-state fMRI (rs-fMRI) scans following administration of either lorazepam (2.5 mg) or placebo. Imaging data were analyzed using an individual brain network parcellation approach and differences in functional connectivity among 78 individual-specific ROIs were estimated. Compared to placebo, functional connectivity was reduced following administration of lorazepam between the left medial paracentral lobule and left temporal pole and between the left posterior cingulate sulcus and right cuneus. Reduced connectivity within higher-order cognitive networks partly supports what has been reported for other benzodiazepines such as midazolam and alprazolam. However, differences across benzodiazepines - possibly due to pharmacokinetics, dosage and receptor selectivity - underscore the need for further research. |
