Keyword search (4,163 papers available)

"Copp W" Authored Publications:

Title Authors PubMed ID
1 DNA Replication across α-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η Tomar R; Ghodke PP; Patra A; Smyth E; Pontarelli A; Copp W; Guengerich FP; Chaput JJ; Wilds CJ; Stone MP; Egli M; 39259676
CHEMBIOCHEM
2 Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing. Copp W, Pontarelli A, Wilds CJ 33506614
CHEMBIOCHEM
3 O6-Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron. Copp W, Wilds CJ 32543755
CHEMBIOCHEM
4 Influence of nucleotide modifications at the C2' position on the Hoogsteen base-paired parallel-stranded duplex of poly(A) RNA. Copp W, Denisov AY, Xie J, Noronha AM, Liczner C, Safaee N, Wilds CJ, Gehring K 28973475
CHEMBIOCHEM
5 Covalent capture of OGT's active site using engineered human-E. coli chimera and intrastrand DNA cross-links. Copp W, O'Flaherty DK, Wilds CJ 30430154
CHEMBIOCHEM

 

Title:Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.
Authors:Copp WPontarelli AWilds CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/33506614
DOI:10.1002/cbic.202000835
Publication:Chembiochem : a European journal of chemical biology
Keywords:DNA nanotechnologybiosensorsdrug deliverynucleic acidsoligonucleotides
PMID:33506614 Category:Chembiochem Date Added:2021-01-29
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec, H4B 1R6, Canada.

Description:

Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.

Chembiochem. 2021 Jan 27; :

Authors: Copp W, Pontarelli A, Wilds CJ

Abstract

The chemical and self-assembly properties of nucleic acids make them ideal for the construction of discrete structures and stimuli-responsive devices for a diverse array of applications. Amongst the various three-dimensional assemblies, DNA tetrahedra are of particular interest as these structures have been shown to be readily taken up by the cell without the need for transfecting agents via the process of caveolin mediated endocytosis. Moreover, these structures can be readily modified with a diverse range of pendant groups to confer greater functionality. This minireview highlights recent examples of advances related to applications of this interesting DNA structure including the delivery of therapeutic agents ranging from small molecules to oligonucleotides in addition to its utilization for sensing and imaging of various species within the cell.

PMID: 33506614 [PubMed - as supplied by publisher]





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