Keyword search (4,163 papers available)

"Cofresí RU" Authored Publications:

Title Authors PubMed ID
1 Cue-alcohol associative learning in female rats. Cofresí RU, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ 31002878
PSYCHOLOGY
2 Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula. Cofresí RU, Grote DJ, Le EVT, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ 30612041
PSYCHOLOGY
3 Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats. Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA 28169439
CSBN
4 Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats. Cofresí RU, Lee HJ, Monfils MH, Chaudhri N, Gonzales RA 29635111
PSYCHOLOGY

 

Title:Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats.
Authors:Cofresí RU,  Lewis SM,  Chaudhri N,  Lee HJ,  Monfils MH,  Gonzales RA
Link:https://www.ncbi.nlm.nih.gov/pubmed/28169439?dopt=Abstract
Publication:
Keywords:
PMID:28169439 Category:Alcohol Clin Exp Res Date Added:2019-05-31
Dept Affiliation: CSBN
1 Institute for Neuroscience, The University of Texas at Austin, Austin, Texas.
2 Department of Psychology, The University of Washington, Seattle, Washington.
3 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
4 Department of Psychology, Institute for Neuroscience, The University of Texas at Austin, Austin, Texas.
5 Division of Pharmacology & Toxicology, Institute for Neuroscience, The University of Texas at Austin, Austin, Texas.

Description:

Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats.

Alcohol Clin Exp Res. 2017 03;41(3):608-617

Authors: Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

Abstract

BACKGROUND: Conditioned responses to alcohol-associated cues can hinder recovery from alcohol use disorder (AUD). Cue exposure (extinction) therapy (CET) can reduce reactivity to alcohol cues, but its efficacy is limited by phenomena such as spontaneous recovery and reinstatement that can cause a return of conditioned responding after extinction. Using a preclinical model of alcohol cue reactivity in rats, we evaluated whether the efficacy of alcohol CET could be improved by conducting CET during the memory reconsolidation window after retrieval of cue-alcohol associations.

METHODS: Rats were provided with intermittent access to unsweetened alcohol. Rats were then trained to predict alcohol access based on a visual cue. Next, rats were treated with either standard extinction (n = 14) or postretrieval extinction (n = 13). Rats were then tested for long-term memory of extinction and susceptibility to spontaneous recovery and reinstatement.

RESULTS: Despite equivalent extinction, rats treated with postretrieval extinction exhibited reduced spontaneous recovery and reinstatement relative to rats treated with standard extinction.

CONCLUSIONS: Postretrieval CET shows promise for persistently attenuating the risk to relapse posed by alcohol cues in individuals with AUD.

PMID: 28169439 [PubMed - indexed for MEDLINE]




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