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PubMed Publications| Keyword search (4,163 papers available) |  |
"Chakravarty M" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Cerebral blood flow in schizophrenia: A systematic review and meta-analysis of MRI-based studies | Percie du Sert O; Unrau J; Gauthier CJ; Chakravarty M; Malla A; Lepage M; Raucher-Chéné D; | 36341843 CRDH |
| 2 | Analyses of microstructural variation in the human striatum using non-negative matrix factorization | Robert C; Patel R; Blostein N; Steele CC; Mallar Chakravarty M; | 34848302 PSYCHOLOGY |
| Title: | Analyses of microstructural variation in the human striatum using non-negative matrix factorization | ||||
| Authors: | Robert C, Patel R, Blostein N, Steele CC, Mallar Chakravarty M | ||||
| Link: | pubmed.ncbi.nlm.nih.gov/34848302/ | ||||
| DOI: | 10.1016/j.neuroimage.2021.118744 | ||||
| Publication: | NeuroImage | ||||
| Keywords: | Franctional anisotropy; Mean diffusivity; Microstructure; Multimodal; Non-negative matrix factorization; Striatum; T1w/T2w; | ||||
| PMID: | 34848302 | Category: | Date Added: | 2021-12-01 | |
| Dept Affiliation: |
PSYCHOLOGY
1 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada. Electronic address: corinne.robert@mail.mcgill.ca. 2 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada. 3 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada. 4 Department of Psychology, Concordia University, Montreal, QC, Canada; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. 5 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada; Dep |
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Description: |
The striatum is a major subcortical connection hub that has been heavily implicated in a wide array of motor and cognitive functions. Here, we developed a normative multimodal, data-driven microstructural parcellation of the striatum using non-negative matrix factorization (NMF) based on multiple magnetic resonance imaging-based metrics (mean diffusivity, fractional anisotropy, and the ratio between T1- and T2-weighted structural) from the Human Connectome Project Young Adult dataset (n=329 unrelated participants, age range: 22-35, F/M: 185/144). We further explored the biological and functional relationships of this parcellation by relating our findings to motor and cognitive performance in tasks known to involve the striatum as well as demographics. We identified 5 spatially distinct striatal components, for each hemisphere. We also show the gain in component stability when using multimodal versus unimodal metrics. Our findings suggest distinct microstructural patterns in the human striatum that are largely symmetric and that relate mostly to age and sex. Our work also highlights the putative functional relevance of these striatal components to different designations based on a Neurosynth meta-analysis. |
