Keyword search (4,163 papers available)

"Brake WG" Authored Publications:

Title Authors PubMed ID
1 Combined effects of the contraceptive hormones, ethinyl estradiol and levonorgestrel, on the use of place and response memory in gonadally-intact female rats Lacasse JM; Boulos V; Fisher C; Hamilton S; Heron M; Mac Cionnaith CE; Peronace V; Tito N; Brake WG; 36403510
PSYCHOLOGY
2 Modeling hormonal contraception in female rats: a framework for studies in behavioral neurobiology Lacasse JM; Gomez-Perales E; Brake WG; 35952797
PSYCHOLOGY
3 Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons Almey A; Milner TA; Brake WG; 35397175
CSBN
4 Progesterone rapidly alters the use of place and response memory during spatial navigation in female rats Lacasse JM; Patel S; Bailey A; Peronace V; Brake WG; 35158200
PSYCHOLOGY
5 Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women Gagne C; Piot A; Brake WG; 35115970
CSBN
6 The priming effect of food persists following blockade of dopamine receptors. Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumrouyan RA, Patel S, Lorenc V, Gagne C, El Oufi K, Shizgal P, Brake WG 31350860
CSBN
7 Estrogen receptor α and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum. Almey A, Milner TA, Brake WG 27080432
PSYCHOLOGY
8 High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats. Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG 27154458
CSBN
9 Modulation of spatial and response strategies by phase of the menstrual cycle in women tested in a virtual navigation task. Hussain D, Hanafi S, Konishi K, Brake WG, Bohbot VD 27213559
PSYCHOLOGY
10 17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo. Shams WM, Sanio C, Quinlan MG, Brake WG 27256507
PSYCHOLOGY
11 Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats. Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG 28062232
PSYCHOLOGY
12 17β-estradiol locally increases phasic dopamine release in the dorsal striatum. Shams WM, Cossette MP, Shizgal P, Brake WG 29175028
CSBN
13 Modulatory effect of 17-β estradiol on performance of ovariectomized rats on the Shock-Probe test. Gervais NJ, Jacob S, Brake WG, Mumby DG 24768650
PSYCHOLOGY
14 Changes in brain volume in response to estradiol levels, amphetamine sensitization and haloperidol treatment in awake female rats. Madularu D, Kulkarni P, Ferris CF, Brake WG 26032742
CSBN
15 Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat. Gervais NJ, Mumby DG, Brake WG 26104963
CSBN
16 Ovarian steroids alter dopamine receptor populations in the medial preoptic area of female rats: implications for sexual motivation, desire, and behaviour. Graham MD, Gardner Gregory J, Hussain D, Brake WG, Pfaus JG 26536143
PSYCHOLOGY
17 High Oestradiol Replacement Reverses Response Memory Bias in Ovariectomised Female Rats Regardless of Dopamine Levels in the Dorsal Striatum. Hussain D, Cossette MP, Brake WG 26929121
PSYCHOLOGY
18 Intra-perirhinal cortex administration of estradiol, but not an ERβ agonist, modulates object-recognition memory in ovariectomized rats. Gervais NJ, Hamel LM, Brake WG, Mumby DG 27321161
PSYCHOLOGY
19 Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum Minogianis EA; Shams WM; Mabrouk OS; Wong JT; Brake WG; Kennedy RT; du Souich P; Samaha AN; 29757478
MASSSPEC

 

Title:Estrogen receptor α and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum.
Authors:Almey A,  Milner TA,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/27080432?dopt=Abstract
DOI:10.1016/j.neulet.2016.04.023
Publication:Neuroscience letters
Keywords:Electron microscopy;  GPR30;  Membrane estrogen receptor alpha;  γ;  -Aminobutyric acid; 
PMID:27080432 Category:Neurosci Lett Date Added:2019-06-20
Dept Affiliation: PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: anne.almey@gmail.com.
2 Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA. Electronic address: tmilner@med.cornell.edu.
3 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: wayne.brake@concordia.ca.

Description:

Estrogen receptor a and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum.

Neurosci Lett. 2016 05 27;622:118-23

Authors: Almey A, Milner TA, Brake WG

Abstract

Estrogens affect dopamine transmission in the striatum, increasing dopamine availability, maintaining D2 receptor density, and reducing the availability of the dopamine transporter. Some of these effects of estrogens are rapid, suggesting that they are mediated by membrane associated receptors. Recently our group demonstrated that there is extra-nuclear labeling for ERa, ERß, and GPER1 in the striatum, but that ERa and GPER1 are not localized to dopaminergic neurons in this region. GABAergic neurons are the most common type of neuron in the striatum, and changes in GABA transmission affect dopamine transmission. Thus, to determine whether ERa or GPER1 are localized to GABAergic neurons, we double labeled the striatum with antibodies for ERa or GPER1 and GABA and examined them using electron microscopy. Ultrastructural analysis revealed that ERa and GPER1 are localized exclusively to extranuclear sites in the striatum, and ~35% of the dendrites and axon terminals labeled for these receptors contain GABA immunoreactivity. Binding at membrane-associated ERa and GPER1 could account for rapid estrogen-induced decreases in GABA transmission in the striatum, which, in turn, could affect dopamine transmission in this region.

PMID: 27080432 [PubMed - indexed for MEDLINE]




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