Keyword search (4,163 papers available)

"Arvanitogiannis A" Authored Publications:

Title Authors PubMed ID
1 Reciprocal effects of single or repeated exposure to methylphenidate or sex in adult male rats Pallikaras V; Mac Cionnaith CE; Rosales VCF; Arvanitogiannis A; Pfaus JG; 36544054
PSYCHOLOGY
2 The trade-off between pulse duration and power in optical excitation of midbrain dopamine neurons approximates Bloch's law Pallikaras V; Carter F; Velazquez-Martinez DN; Arvanitogiannis A; Shizgal P; 34864162
PSYCHOLOGY
3 Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior. Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C 30295713
PSYCHOLOGY
4 Differential sensitivity to the acute and sensitizing behavioral effects of methylphenidate as a function of strain in adolescent and young adult rats. Yetnikoff L, Arvanitogiannis A 24134881
CSBN
5 Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates. Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF 24138924
CSBN
6 Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids. Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, Arvanitogiannis A, Alquier T, Fulton S 26171719
CSBN
7 Non-Contingent Exposure to Amphetamine in Adolescence Recruits miR-218 to Regulate Dcc Expression in the VTA. Cuesta S, Restrepo-Lozano JM, Silvestrin S, Nouel D, Torres-Berrío A, Reynolds LM, Arvanitogiannis A, Flores C 29154364
CSBN
8 Adolescent Exposure to Methylphenidate Increases Impulsive Choice Later in Life. Abbas Z, Sweet A, Hernandez G, Arvanitogiannis A 29163086
CSBN

 

Title:Differential sensitivity to the acute and sensitizing behavioral effects of methylphenidate as a function of strain in adolescent and young adult rats.
Authors:Yetnikoff L,  Arvanitogiannis A
Link:https://www.ncbi.nlm.nih.gov/pubmed/24134881?dopt=Abstract
Publication:
Keywords:
PMID:24134881 Category:Behav Brain Funct Date Added:2019-05-31
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. a.arvanitogiannis@concordia.ca.

Description:

Differential sensitivity to the acute and sensitizing behavioral effects of methylphenidate as a function of strain in adolescent and young adult rats.

Behav Brain Funct. 2013 Oct 17;9:38

Authors: Yetnikoff L, Arvanitogiannis A

Abstract

BACKGROUND: Behavioral effects of stimulant drugs are influenced by non-pharmacological factors, including genetic variability and age. We examined acute and sensitized locomotor effects of methylphenidate in adolescent and early adult male Sprague Dawley (SD), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats using a drug regimen that differentiates clearly between initial and enduring differences in drug responsiveness. We probed for strain and age differences in the sensitizing effects of methylphenidate using a cocaine challenge. Methylphenidate was administered to the rats in a non-home environment.

FINDINGS: Strain differences in sensitivity to single methylphenidate injections depend on age and change with continuing drug pretreatment. While SHR rats are more sensitive to methylphenidate relative to WKY regardless of age and pretreatment day, SHR rats become more sensitive to methylphenidate than SD rats towards the end of pretreatment during early adulthood. SD rats exhibit greater sensitivity to methylphenidate relative to the WKY group during adolescence, an effect that dissipates with continued drug pretreatment during adulthood. Remarkably, only SHR rats, regardless of age, exhibit methylphenidate-induced cross-sensitization to the behavioral effects of cocaine.

CONCLUSIONS: Our findings suggest that SHR rats are more vulnerable than other strains to methylphenidate-induced cross-sensitization to cocaine, at least when methylphenidate is administered in a non-home environment. Given that SHR rats are typically used to model features of attention deficit hyperactivity disorder, these findings may have important implications for the treatment of this disorder with methylphenidate.

PMID: 24134881 [PubMed - indexed for MEDLINE]




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