Keyword search (4,163 papers available)

"Alazi E" Authored Publications:

Title Authors PubMed ID
1 An Evolutionarily Conserved Transcriptional Activator-Repressor Module Controls Expression of Genes for D-Galacturonic Acid Utilization in Aspergillus niger. Niu J, Alazi E, Reid ID, Arentshorst M, Punt PJ, Visser J, Tsang A, Ram AF 28049705
CSFG
2 The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger. Alazi E, Khosravi C, Homan TG, du Pré S, Arentshorst M, Di Falco M, Pham TTM, Peng M, Aguilar-Pontes MV, Visser J, Tsang A, de Vries RP, Ram AFJ 28417461
CSFG
3 W361R mutation in GaaR, the regulator of D-galacturonic acid-responsive genes, leads to constitutive production of pectinases in Aspergillus niger. Alazi E, Niu J, Otto SB, Arentshorst M, Pham TTM, Tsang A, Ram AFJ 30298571
CSFG

 

Title:The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger.
Authors:Alazi E,  Khosravi C,  Homan TG,  du Pré S,  Arentshorst M,  Di Falco M,  Pham TTM,  Peng M,  Aguilar-Pontes MV,  Visser J,  Tsang A,  de Vries RP,  Ram AFJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/28417461?dopt=Abstract
DOI:10.1002/1873-3468.12654
Publication:FEBS letters
Keywords:d-galacturonic acid catabolism;  gene regulation;  pectinase; 
PMID:28417461 Category:FEBS Lett Date Added:2019-06-07
Dept Affiliation: CSFG
1 Molecular Microbiology and Biotechnology, Institute of Biology Leiden, Leiden University, The Netherlands.
2 Fungal Physiology, Westerdijk Fungal Biodiversity Institute, Utrecht University, The Netherlands.
3 Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada.

Description:

The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger.

FEBS Lett. 2017 05;591(10):1408-1418

Authors: Alazi E, Khosravi C, Homan TG, du Pré S, Arentshorst M, Di Falco M, Pham TTM, Peng M, Aguilar-Pontes MV, Visser J, Tsang A, de Vries RP, Ram AFJ

Abstract

In Aspergillus niger, the enzymes encoded by gaaA, gaaB, and gaaC catabolize d-galacturonic acid (GA) consecutively into l-galactonate, 2-keto-3-deoxy-l-galactonate, pyruvate, and l-glyceraldehyde, while GaaD converts l-glyceraldehyde to glycerol. Deletion of gaaB or gaaC results in severely impaired growth on GA and accumulation of l-galactonate and 2-keto-3-deoxy-l-galactonate, respectively. Expression levels of GA-responsive genes are specifically elevated in the ?gaaC mutant on GA as compared to the reference strain and other GA catabolic pathway deletion mutants. This indicates that 2-keto-3-deoxy-l-galactonate is the inducer of genes required for GA utilization.

PMID: 28417461 [PubMed - indexed for MEDLINE]




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