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PubMed Publications| Keyword search (4,163 papers available) |  |
"Afnan J" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia | Heers M; Afnan J; Braun C; Grova C; Altenmüller DM; Steinhoff BJ; Dümpelmann M; Demerath T; Urbach H; Ethofer S; Siegel M; Schulze-Bonhage A; Lerche H; Li Hegner Y; | 41804684 PERFORM |
| 2 | How vigilance states influence source imaging of physiological brain oscillations: evidence from intracranial EEG | Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B; | 41687693 SOH |
| 3 | EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy | Afnan J; Cai Z; Lina JM; Abdallah C; Delaire E; Avigdor T; Ros V; Hedrich T; von Ellenrieder N; Kobayashi E; Frauscher B; Gotman J; Grova C; | 38994740 SOH |
| 4 | Consistency of electrical source imaging in presurgical evaluation of epilepsy across different vigilance states | Avigdor T; Abdallah C; Afnan J; Cai Z; Rammal S; Grova C; Frauscher B; | 38217279 PERFORM |
| 5 | Validating MEG source imaging of resting state oscillatory patterns with an intracranial EEG atlas | Afnan J; von Ellenrieder N; Lina JM; Pellegrino G; Arcara G; Cai Z; Hedrich T; Abdallah C; Khajehpour H; Frauscher B; Gotman J; Grova C; | 37149236 PERFORM |
| 6 | Clinical Yield of Electromagnetic Source Imaging and Hemodynamic Responses in Epilepsy: Validation With Intracerebral Data | Abdallah C; Hedrich T; Koupparis A; Afnan J; Hall JA; Gotman J; Dubeau F; von Ellenrieder N; Frauscher B; Kobayashi E; Grova C; | 35473762 PERFORM |
| Title: | Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia | ||||
| Authors: | Heers M, Afnan J, Braun C, Grova C, Altenmüller DM, Steinhoff BJ, Dümpelmann M, Demerath T, Urbach H, Ethofer S, Siegel M, Schulze-Bonhage A, Lerche H, Li Hegner Y | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41804684/ | ||||
| DOI: | 10.1002/epi.70191 | ||||
| Publication: | Epilepsia | ||||
| Keywords: | focal cortical dysplasia; focal epilepsy; magnetic source imaging; seizures; sleep; | ||||
| PMID: | 41804684 | Category: | Date Added: | 2026-03-10 | |
| Dept Affiliation: |
PERFORM
1 Epilepsy Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 2 Multimodal Functional Imaging Lab, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 3 Magnetoencephalography Center, University of Tübingen, Tübingen, Germany. 4 Department of Neural Dynamics and Magnetoencephalography, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. 5 Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany. 6 Centre De Recherches Mathématiques, Montreal, Quebec, Canada. 7 Multimodal Functional Imaging Lab, Department of Physics and PERFORM Center, Concordia University, Montreal, Quebec, Canada. 8 Epilepsy Center Kork, Kehl-Kork, Germany. 9 Department of Microsystems Engineering-IMTEK, University of Freiburg, Freiburg, Germany. 10 BrainLinks-BrainTools Center, University of Freiburg, Freiburg, Germany. 11 Department of Neuroradiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 12 Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany. 13 Center for Bionic Intelligence Tübingen Stuttgart, Tübingen, Germany. 14 German Center for Mental Health, Tübingen, Germany. 15 Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. |
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Description: |
Objective: Focal cortical dysplasia (FCD) causes drug-resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14-40 Hz) and gamma (40-80 Hz) frequency bands, and seizures. This study aimed to quantify sleep-associated changes in IEDs, FOs, and seizures in FCD patients using noninvasive magnetoencephalography (MEG). Methods: Nineteen patients with FCD were prospectively recruited and underwent simultaneous MEG/EEG recordings lasting 89 ± 19 min during daytime sleep. Sleep stages were classified from the EEG. Beamformer source signals were computed from the MEG signal to enhance sensitivity for visual detection of IEDs, FOs in the beta and gamma frequency bands, and seizures. Magnetic source imaging (MSI) was performed using the Maximum Entropy on the Mean (MEM) method, which is particularly sensitive to the spatial extent of sources, enabling accurate localization of epileptic activity. Results: N1 sleep was reached in 17 of 19 patients and N2 sleep in 14 of 19 patients. Compared to wakefulness, sleep recordings showed significantly higher rates of FOs and seizures (both p < .05), whereas IED rates showed nonsignificant trends. Ten patients demonstrated FOs or seizures, and 12 showed IEDs. MSI of IEDs demonstrated consistent accuracy across vigilance states, with median Euclidean distances of 12.74 mm (interquartile range [IQR] = 22.74) in wake and 8.34 mm (IQR = 27.58) in sleep, and no systematic amplitude or spatial extent changes. Wavelet-MEM enabled frequency-specific source imaging, with FOs and seizures localizing concordantly to FCD lesions in five of seven and seven of eight patients, respectively. Significance: Daytime sleep MEG recordings are clinically feasible and significantly enhance the detection of seizures (37% of patients) and FOs compared to wakefulness. Sleep protocols enable noninvasive capture of ictal patterns-the gold standard for epileptogenic zone localization-alongside increased FO rates. These findings support incorporating sleep into standard MEG protocols for presurgical epilepsy evaluation. |
