1 Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada. Electronic address: anoosha.attaran@usask.ca.
2 Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada.
3 Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada; Department of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada.
4 Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada; Department of Biology, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec, H4B 1R6, Canada.
5 Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada; Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan, S7N 5B3, Canada.

Effects of chronic exposure to selenomethionine on social learning outcomes in zebrafish (Danio rerio): serotonergic dysregulation and oxidative stress in the brain.

Chemosphere. 2020 Jan 11;247:125898

Authors: Attaran A, Salahinejad A, Naderi M, Crane AL, Niyogi S, Chivers DP

Abstract

For many species, social learning is crucial for fitness-related activities, but human-induced environmental changes can impair such learning processes. For instance, mining can release the element, selenium (Se), that is vital for physiological functions but also has toxicological properties at elevated concentrations. In this study, we investigated the effects of chronic exposure to Se on social learning outcomes and potential underlying molecular mechanisms in adult zebrafish. After exposure to different levels of dietary selenomethionine (control, 3.6, 12.8, 34.1 µg Se/g dry weight) for 90 days, we examined the ability of observer fish to follow demonstrators (experienced individuals) in escaping an oncoming trawl. Social learning outcomes were then assessed in the absence of demonstrators. Our results indicated that fish in the highest exposure group (34.1 µg/g) displayed significantly slower escape responses compared to fish in the control and lower exposure groups (3.6 and 12.8 µg Se/g). This impaired behavior was associated with higher oxidative stress and dysregulation in genes that are key in the serotonergic pathway, indicating that oxidative stress and alteration in the serotonergic system lead to impairment of social learning.

PMID: 31972490 [PubMed - as supplied by publisher]