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Exploiting fluctuations in gene expression to detect causal interactions between genes

Author(s): Joly-Smith E; Talpur MM; Allard P; Papazotos F; Potvin-Trottier L; Hilfinger A;

Characterizing and manipulating cellular behavior requires a mechanistic understanding of the causal interactions between cellular components. We present an approach to detect causal interactions between genes without the need to perturb the physiological state of cells. This approach exploits naturally occurring cell-to-cell variability which is experime ...

Article GUID: 41401079


Child and marital stress are associated with a psychophysiological index of self-regulatory capacities among parents of preschool children

Author(s): MacNeil S; da Estrela C; Caldwell W; Gouin JP;

Objective: A parent's ability to self-regulate influences parenting practices. Child-related stressors may deplete parent's self-regulatory capacities. However, this effect may be moderated by the marital context within which stressful parent-child interactions are occurring. The aim of the current study was to investigate the association between ...

Article GUID: 40972822


Global survey of secondary metabolism in em Aspergillus niger /em via activation of specific transcription factors

Author(s): Semper C; Pham TTM; Ram S; Palys S; Evdokias G; Ouedraogo JP; Moisan MC; Geoffrion N; Reid I; Di Falco M; Bailey Z; Tsang A; Benoit-Gelber I; Savchenko A;

Genomics analysis confirmed the status of filamentous fungi as a rich source of novel secondary metabolites; however, the discovery of these compounds is hampered by the cryptic nature of their biosynthetic pathways under laboratory conditions. Consequently, despite substantial research effort ov ...

Article GUID: 40852424


Protecting shorelines in Canadian Indigenous communities: Environmental challenges, policy interventions, and mitigation technologies

Author(s): Iravani R; Biagi M; Laforest S; Lee K; Isaacman L; Chen Z; An C;

There is growing concern regarding the environmental protection of shorelines in Canadian Indigenous communities, as these regions face increasing threats from pollution and environmental degradation. This review examines various types of pollution affecting coastal Indigenous communities, such as oil spills, plastic waste, industrial runoff, and other co ...

Article GUID: 40554913


Identification and comprehensive characterization of moral disapproval and behavioral dysregulation-based pornography-use profiles across 42 countries

Author(s): Bothe B; Tóth-Király I; Popova N; Nagy L; Koós M; Demetrovics Z; Potenza MN; Kraus SW; Ballester-Arnal R; Batthyány D; Bergeron S; Billieux J; Briken P; Burkauskas J; Cárdenas-López G; Carvalho J; Castro-Calvo J; Chen L; Ciocca G; Corazz ...

Background and aims: The Moral Incongruence Model of Pornography Use proposes that pornography-use-related problems may be present due to problematic pornography use (PPU) and/or moral disapproval (MD) of pornography use. Despite some supporting empirical evidence, no study has tested the presenc ...

Article GUID: 39945767


Oil spills in coastal regions of the Arctic and Subarctic: Environmental impacts, response tactics, and preparedness

Author(s): Bi H; Wang Z; Yue R; Sui J; Mulligan CN; Lee K; Pegau S; Chen Z; An C;

Coastal areas of the Arctic and Subarctic are vulnerable to accidental oil spills, impacting the ecosystem, society, and economy. This article provides a comprehensive overview of oil spill pollution issues in cold regions, focusing on environmental impacts, oil transport and fate, coastal/shoreline response measures, and the state of current internationa ...

Article GUID: 39689468


Fe/GMP functional nanomaterial enhancing the denitrification efficiency by bi-signal regulation: Electron transfer and microbial community

Author(s): Hao Y; Guo T; Li H; Liu W; Chen Z; Zhang W; Wang X; Guo J;

A novel functional nanomaterial composed of guanosine monophosphate (GMP) and Fe enhanced denitrification efficiency by regulating electron transfer and microbial community. Fe/GMP enhanced nitrate (NO3-) degradation rates by 3.00-fold in serum vial batch experiments, with a rate constant of 17.39 mg/(L·h) in sequencing batch reactor. Fe/GMP-mediated inte ...

Article GUID: 39326537


Who Should Decide How Machines Make Morally Laden Decisions?

Author(s): Dominic Martin

Who should decide how a machine will decide what to do when it is driving a car, performing a medical procedure, or, more generally, when it is facing any kind of morally laden decision? More and more, machines are making complex decisions with a considerable level of autonomy. We should be much more preoccupied by this problem than we currently are. Afte ...

Article GUID: 27905083


Gambling Patterns and Problems of Gamblers on Licensed and Unlicensed Sites in France

Author(s): Costes JM; Kairouz S; Eroukmanoff V; Monson E;

In 2010 France enacted a law to regulate supply and consumption of online gambling. Its primary aim was to protect citizens from gambling-related harm. This study aims to assess differences in gambling patterns and related harm between online gamblers who use licensed versus unlicensed sites. Participants (N = 3860) completed a self-administered online su ...

Article GUID: 25862019


A cross-cultural comparison of population gambling patterns and regulatory frameworks: France and Québec

Author(s): Kairouz S; Paradis C; Nadeau L; Tovar ML; Pousset M;

Few empirical studies have examined the relationships between differing regulatory approaches and patterns of gambling behaviors. This article reports on a correlational cross-cultural comparison of differences in the regulatory approaches and gambling behavior among general adult populations in France and Québec, Canada. We drew data from two large popul ...

Article GUID: 27171860


Identification of a Conserved Transcriptional Activator-Repressor Module Controlling the Expression of Genes Involved in Tannic Acid Degradation and Gallic Acid Utilization in Aspergillus niger

Author(s): Arentshorst M; Falco MD; Moisan MC; Reid ID; Spaapen TOM; van Dam J; Demirci E; Powlowski J; Punt PJ; Tsang A; Ram AFJ;

Tannic acid, a hydrolysable gallotannin present in plant tissues, consists of a central glucose molecule esterified with gallic acid molecules. Some microorganisms, including several Aspergillus species, can metabolize tannic acid by releasing gallic acid residues from tannic acid by secreting ta ...

Article GUID: 37744122


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