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Combining Pr3+-Doped Nanoradiosensitizers and Endogenous Protoporphyrin IX for X-ray-Mediated Photodynamic Therapy of Glioblastoma Cells

Author(s): Mandl GA; Vettier F; Tessitore G; Maurizio SL; Bietar K; Stochaj U; Capobianco JA;

Glioblastoma multiforme is an aggressive type of brain cancer with high recurrence rates due to the presence of radioresistant cells remaining after tumor resection. Here, we report the development of an X-ray-mediated photodynamic therapy (X-PDT) system using NaLuF4:25% Pr3+ radioluminescent nanoparticles in conjunction with protoporphyrin IX (PPIX), an ...

Article GUID: 37267436


Improving 3D ultrasound prostate localisation in radiotherapy through increased automation of interfraction matching.

Author(s): Grimwood A, Rivaz H, Zhou H, McNair HA, Yakubowski K, Bamber JC, Tree AC, Harris EJ

Radiother Oncol. 2020 May 06;: Authors: Grimwood A, Rivaz H, Zhou H, McNair HA, Yakubowski K, Bamber JC, Tree AC, Harris EJ

Article GUID: 32387546


Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts

Author(s): Behmand B; Noronha AM; Wilds CJ; Marignier JL; Mostafavi M; Wagner JR; Hunting DJ; Sanche L;

Double-stranded oligonucleotides containing cisplatin adducts, with and without a mismatched region, were exposed to hydrated electrons generated by gamma-rays. Gel electrophoresis analysis demonstrates the formation of cisplatin-interstrand crosslinks from the cisplatin-intrastrand species. The ...

Article GUID: 32211848


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