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What can optimized cost distances based on genetic distances offer? A simulation study on the use and misuse of ResistanceGA

Author(s): Daniel A; Savary P; FoltĂȘte JC; Vuidel G; Faivre B; Garnier S; Khimoun A;

Modelling population connectivity is central to biodiversity conservation and often relies on resistance surfaces reflecting multi-generational gene flow. ResistanceGA (RGA) is a common optimization framework for parameterizing these surfaces by maximizing the fit between genetic distances and cost distances using maximum likelihood population effect mode ...

Article GUID: 39417711


Topology optimization of adaptive sandwich plates with magnetorheological core layer for improved vibration attenuation

Author(s): Zare M; Sedaghati R;

In this study the optimum topology distribution of the magnetorheological elastomer (MRE) layer in an adaptive sandwich plate is investigated. The adaptive sandwich plate consists of an MR elastomer layer embedded between two thin elastic plates. A finite element model has been first formulated to derive the governing equations of motion. A design optimiz ...

Article GUID: 39398530


Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM; Ryan S; Raphael S; van Faassen H; Zafer A; Zhu Q; Maclean S; Chattopadhyay A; Gurnani K; Gilber ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains common. Camelid single-domain antibodies (sdAbs or nanobodies) are smaller, simpler, and easier to reco ...

Article GUID: 38596311


Design Optimization of a Hybrid-Driven Soft Surgical Robot with Biomimetic Constraints

Author(s): Roshanfar M; Dargahi J; Hooshiar A;

The current study investigated the geometry optimization of a hybrid-driven (based on the combination of air pressure and tendon tension) soft robot for use in robot-assisted intra-bronchial intervention. Soft robots, made from compliant materials, have gained popularity for use in surgical interventions due to their dexterity and safety. The current stud ...

Article GUID: 38275456


Alternating direction method of multipliers for displacement estimation in ultrasound strain elastography

Author(s): Md Ashikuzzaman

CONCLUSIONS: A novel ultrasonic displacement tracking algorithm named ALTRUIST has been developed. The principal novelty of ALTRUIST is incorporating ADMM for optimizing an L 1 $L1$ -norm regularization-based cost function. ALTRUIST exhibits promising performance in simulation, phantom, and in vivo experiments.

Article GUID: 38159299


Lactate's behavioral switch in the brain: An in-silico model

Author(s): Soltanzadeh M; Blanchard S; Soucy JP; Benali H;

Emerging evidence emphasizes lactate's involvement in both physiological processes (energy metabolism, memory, etc.) and disease (traumatic brain injury, epilepsy, etc.). Furthermore, the usefulness of mathematical modeling in deciphering underlying dynamics of the brain to investigate lactate roles and mechanisms of action has been well established. ...

Article GUID: 37865309


Data-Weighted Multivariate Generalized Gaussian Mixture Model: Application to Point Cloud Robust Registration

Author(s): Ge B; Najar F; Bouguila N;

In this paper, a weighted multivariate generalized Gaussian mixture model combined with stochastic optimization is proposed for point cloud registration. The mixture model parameters of the target scene and the scene to be registered are updated iteratively by the fixed point method under the framework of the EM algorithm, and the number of components is ...

Article GUID: 37754943


Design optimization and experimental evaluation of a large capacity magnetorheological damper with annular and radial fluid gaps

Author(s): Abdalaziz M; Sedaghati R; Vatandoost H;

This paper presents an optimal design of a large-capacity Magnetorheological (MR) damper suitable for off-road vehicle applications. The damper includes an MR fluid bypass valve with both annular and radial gaps to generate a large damping force and dynamic range. An analytical model of the proposed damper is formulated based on the Bingham plastic model ...

Article GUID: 37521729


Designing a multi-objective closed-loop supply chain: a two-stage stochastic programming, method applied to the garment industry in Montréal, Canada

Author(s): Shafiee Roudbari E; Fatemi Ghomi SMT; Eicker U;

The global population continues to grow, which expands demand for raw materials. Meanwhile, governments are developing circular economy strategies within cities and their industries. A circular economy utilizes refurbishing, reusing, remanufacturing, and repairing of products and materials. For companies, this involves to set targets and to rethink their ...

Article GUID: 36747987


Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications

Author(s): Delavari MM; Ocampo I; Stiharu I;

This paper utilizes response surface methodology (RSM) design-based analyses to optimize starch-based wound dressings that were characterized based on weight loss (WL%), swelling index (SI%), and mechanical strength (TS). The wound-dressing materials were prepared by employing a modified casting method, using various concentrations of starch (0.5-2 w/w%), ...

Article GUID: 36557445


A flexible robust model for blood supply chain network design problem

Author(s): Khalilpourazari S; Hashemi Doulabi H;

World Health Organization (WHO) declared COVID-19 as a pandemic On March 12, 2020. Up to January 13, 2022, 320,944,953 cases of infection and 5,539,160 deaths have been reported worldwide. COVID-19 has negatively impacted the blood supply chain by drastically reducing blood donation. Therefore, developing models to design effective blood supply chains in ...

Article GUID: 35474752


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