Author(s): Pontarelli A; Wilds CJ;

The promise of the antisense approach to treat a variety of diseases with oligonucleotides and solutions to challenges that have been encountered in their development is attributable to chemical modification of the nucleic acid scaffold. Herein, we describe preliminary data regarding the synthesis of a novel C5-propynyl-ß-D-arabinouridine (araUP) phosphor ...

Article GUID: 35452799

Author(s): Holgersen EM; Gandhi S; Zhou Y; Kim J; Vaz B; Bogojeski J; Bugno M; Shalev Z; Cheung-Ong K; Gonçalves J; O' Hara M; Kron K; Verby M; Sun M; Kakaradov B; Delong A; Merico D; Deshwar AG;

Steric-blocking oligonucleotides (SBOs) are short, single-stranded nucleic acids designed to modulate gene expression by binding to RNA transcripts and blocking access from cellular machinery such as splicing factors. SBOs have the potential to bind to near-complementary sites in the transcriptom ...

Article GUID: 34388351

Author(s): Liczner C; Duke K; Juneau G; Egli M; Wilds CJ;

Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their scaffold, prepared with modified nucleosides and solid-phase synthesis, have yielded molecules with in ...

Article GUID: 33981365

Author(s): Copp W, Pontarelli A, Wilds CJ

The chemical and self-assembly properties of nucleic acids make them ideal for the construction of discrete structures and stimuli-responsive devices for a diverse array of applications. Amongst the various three-dimensional assemblies, DNA tetrahedra are of particular interest as these structures have been shown to be readily taken up by the cell without ...

Article GUID: 33506614

Author(s): O'Flaherty DK, Wilds CJ

Chem Asian J. 2016 Feb 18;11(4):576-83 Authors: O'Flaherty DK, Wilds CJ

Article GUID: 26692563