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Computational neuroscience across the lifespan: Promises and pitfalls

Author(s): van den Bos W; Bruckner R; Nassar MR; Mata R; Eppinger B;

In recent years, the application of computational modeling in studies on age-related changes in decision making and learning has gained in popularity. One advantage of computational models is that they provide access to latent variables that cannot be directly observed from behavior. In combination with experimental manipulations, these latent variables c ...

Article GUID: 29066078


Overcoming boundaries: Interdisciplinary challenges and opportunities in cognitive neuroscience

Author(s): Brignol A; Paas A; Sotelo-Castro L; St-Onge D; Beltrame G; Coffey EBJ;

Cognitive neuroscience has considerable untapped potential to translate our understanding of brain function into applications that maintain, restore, or enhance human cognition. Complex, real-world phenomena encountered in daily life, professional contexts, and in the arts, can also be a rich source of information for better understanding cognition, which ...

Article GUID: 38750788


Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice

Author(s): Roque PS; Thörn Perez C; Hooshmandi M; Wong C; Eslamizade MJ; Heshmati S; Brown N; Sharma V; Lister KC; Goyon VM; Neagu-Lund L; Shen C; Daccache N; Sato H; Sato T; Mogil JS; Nader K; Gkogkas CG; Iordanova MD; Prager-Khoutorsky M; McBride ...

Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species. The mechanisms underlying long-lasting impairment in cognitive function are poorly understood. Here, we show that repeated genera ...

Article GUID: 36394958


Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity

Author(s): Pepin AB; Harel Y; O' Byrne J; Mageau G; Dietrich A; Jerbi K;

Creativity is a highly valued and beneficial skill that empirical research typically probes using "divergent thinking" (DT) tasks such as problem solving and novel idea generation. Here, in contrast, we examine the perceptual aspect of creativity by asking whether creative individuals are more likely to perceive recognizable forms in ambiguous stimuli -a ...

Article GUID: 36164655


Sigma oscillations protect or reinstate motor memory depending on their temporal coordination with slow waves

Author(s): Nicolas J; King BR; Levesque D; Lazzouni L; Coffey EBJ; Swinnen S; Doyon J; Carrier J; Albouy G;

Targeted memory reactivation (TMR) during post-learning sleep is known to enhance motor memory consolidation but the underlying neurophysiological processes remain unclear. Here, we confirm the beneficial effect of auditory TMR on motor performance. At the neural level, TMR enhanced slow wave (SW ...

Article GUID: 35726850


The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle

Author(s): Pallikaras V; Shizgal P;

Deep-brain stimulation of the medial forebrain bundle (MFB) can provide effective, enduring relief of treatment-resistant depression. Panksepp provided an explanatory framework: the MFB constitutes the core of the neural circuitry subserving the anticipation and pursuit of rewards: the "SEEKING" system. On that view, the SEEKING system is hypoactive in de ...

Article GUID: 35431828


The Algorithms of Mindfulness

Author(s): Johannes Bruder

This paper analyzes notions and models of optimized cognition emerging at the intersections of psychology, neuroscience, and computing. What I somewhat polemically call the algorithms of mindfulness describes an ideal that determines algorithmic techniques of the self, geared at emotional resilience and creative cognition. A reframing of rest, exemplified ...

Article GUID: 35103028


Comment on the article "Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome 486 (2020) 110102"

Author(s): Arsalan Rahimabadi

Considering the reaction schemes (20) and (21) in Fornari et al., 2020, the fragmentation terms Fi (Eq. (22) in Fornari et al., 2020) are not correct. Thus, the fragmentation terms Fi (Eq. (12) in Fornari et al., 2020) are also incorrect when the reaction schemes (10) and (11) in Fornari et al., 2020 are taken into account. Here, the correct equations wil ...

Article GUID: 34843739


The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

Author(s): Paquola C; Royer J; Lewis LB; Lepage C; Glatard T; Wagstyl K; DeKraker J; Toussaint PJ; Valk SL; Collins DL; Khan A; Amunts K; Evans AC; Dickscheid T; Bernhardt BC;

Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is 'BigBrain'. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, 'BigBra ...

Article GUID: 34431476


All-optical approaches to studying psychiatric disease

Author(s): Lafferty CK; Christinck TD; Britt JP;

Improvements in all-optical means of monitoring and manipulating neural activity have generated new ways of studying psychiatric disease. The combination of calcium imaging techniques with optogenetics to concurrently record and manipulate neural activity has been used to create new disease models that link distinct circuit abnormalities to specific disea ...

Article GUID: 34314828


Meta-control: From psychology to computational neuroscience

Author(s): Eppinger B; Goschke T; Musslick S;

Research in the past decades shed light on the different mechanisms that underlie our capacity for cognitive control. However, the meta-level processes that regulate cognitive control itself remain poorly understood. Following the terminology from artificial intelligence, meta-control can be defined as a collection of mechanisms that (a) monitor the progr ...

Article GUID: 34081267


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