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Cell Fate Dynamics Reconstruction Identifies TPT1 and PTPRZ1 Feedback Loops as Master Regulators of Differentiation in Pediatric Glioblastoma-Immune Cell Networks

Author(s): Abicumaran Uthamacumaran

Pediatric glioblastoma is a complex dynamical disease that is difficult to treat due to its multiple adaptive behaviors driven largely by phenotypic plasticity. Integrated data science and network theory pipelines offer novel approaches to studying glioblas ...

Article GUID: 39420135


What can optimized cost distances based on genetic distances offer? A simulation study on the use and misuse of ResistanceGA

Author(s): Daniel A; Savary P; Foltête JC; Vuidel G; Faivre B; Garnier S; Khimoun A;

Modelling population connectivity is central to biodiversity conservation and often relies on resistance surfaces reflecting multi-generational gene flow. ResistanceGA (RGA) is a common optimization framework for parameterizing these surfaces by maximizing ...

Article GUID: 39417711


Topology optimization of adaptive sandwich plates with magnetorheological core layer for improved vibration attenuation

Author(s): Zare M; Sedaghati R;

In this study the optimum topology distribution of the magnetorheological elastomer (MRE) layer in an adaptive sandwich plate is investigated. The adaptive sandwich plate consists of an MR elastomer layer embedded between two thin elastic plates. A finite e ...

Article GUID: 39398530


Altered Amplitude of Low-Frequency Fluctuations of rs-fMRI Signal followed by rTMS Analgesic Effects in Non-Specific Chronic Low Back Pain (CLBP) Patients

Author(s): Masoumbeigi M; Riyahi Alam N; Kordi R; Rostami M; Rahimiforoushani A; Jafari AH; Hashemi H; Ebrahimpour A; ...

Background: Non-specific chronic low back pain (CLBP) is a common painful condition and is responsible for different physical disorders. Despite alternative therapies, patients still suffer from pe ...

Article GUID: 39391282


Transcriptomics identify the triggering of citrate export as the key event caused by manganese deficiency in Aspergillus niger

Author(s): Fekete E; Bíró V; Márton A; Bakondi-Kovács I; Sándor E; Kovács B; Geoffrion N; Tsang A; Kubicek CP; Karaffa L; ...

For over a century, the filamentous Ascomycete fungus Aspergillus niger has played a pivotal role in the industrial production of citric acid. A critical fermentation parameter that sustains high-y ...

Article GUID: 39377610


Bismuth-Tin Core-Shell Particles From Liquid Metals: A Novel, Highly Efficient Photothermal Material that Combines Broadband Light Absorption with Effective Light-to-Heat Conversion

Author(s): Seyda D; Dincer O; Ince D; Cugunlular M; Unalan HE; Çinar Aygün S;

This study presents a pioneering investigation of hybrid bismuth-tin (BiSn) liquid metal particles for photothermal applications. It is shown that the intrinsic core-shell structure of liquid metal particles can be instrumentalized to combine the broadband ...

Article GUID: 39375946


Crystal structure and Hirshfeld surface analysis of tri-chlorido-(1,10-phenanthroline-κ2 N,N')phenyltin(IV)

Author(s): Benlatreche T; Bensegueni MA; Dénès G; Golhen S; Merazig H;

The title compound, [Sn(C6H5)Cl3(C12H8N2)], which was obtained by the reaction between 1,10-phenanthroline and phenyl-tin trichloride in methanol, exhibits intra-molecular hydrogen-bonding inter-actions involving the chlorine and hydrogen atoms. Crystal coh ...

Article GUID: 39372187


Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

Author(s): Samuel Olajide T; Oyerinde TO; Omotosho OI; Okeowo OM; Olajide OJ; Ijomone OM;

The existing literature on neurodegenerative diseases (NDDs) reveals a common pathological feature: the accumulation of misfolded proteins. However, the heterogeneity in disease onset mechanisms and the specific brain regions affected complicates the unders ...

Article GUID: 39364217


Challenges and Approaches in the Study of Neural Entrainment

Author(s): Duecker K; Doelling KB; Breska A; Coffey EBJ; Sivarao DV; Zoefel B;

When exposed to rhythmic stimulation, the human brain displays rhythmic activity across sensory modalities and regions. Given the ubiquity of this phenomenon, how sensory rhythms are transformed into neural rhythms remains surprisingly inconclusive. An infl ...

Article GUID: 39358026


The temporal sequence and reciprocal relationships of frailty, social isolation and loneliness in older adults across 21 years

Author(s): Mehrabi F; Pomeroy ML; Cudjoe TKM; Jenkins E; Dent E; Hoogendijk EO;

Background: It is unclear whether social isolation and loneliness may precede frailty status or whether frailty may precipitate social isolation and loneliness. We investigated the reciprocal and temporal sequence of social isolation, loneliness, and frailt ...

Article GUID: 39360435


Reduction of Cr(VI) by Bacillus toyonensis LBA36 and its effect on radish seedlings under Cr(VI) stress

Author(s): Tan A; Wang H; Zhang H; Zhang L; Yao H; Chen Z;

Chromium, being among the most toxic heavy metals, continues to demand immediate attention in the remediation of Cr-contaminated environments. In this study, a strain of LBA36 (Bacillus toyonensis) was isolated from heavy metal contaminated soil in Luanchua ...

Article GUID: 39346031


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