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The effects of acute exercise and a nap on heart rate variability and memory in young sedentary adults

Author(s): Mograss M; Frimpong E; Vilcourt F; Chouchou F; Zvionow T; Dang-Vu TT;

Recent evidence suggests that the autonomic nervous system can contribute to memory consolidation during sleep. Whether fluctuations in cardiac autonomic activity during sleep following physical exercise contribute to the process of memory consolidation has not been studied. We assessed the effects of a non-rapid eye movement (NREM) nap following acute ex ...

Article GUID: 37855092


Inhibiting amyloid beta (1-42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex

Author(s): Olajide OJ; La Rue C; Bergdahl A; Chapman CA;

Increasing evidence suggests that mitochondrial dysfunction and aberrant release of mitochondrial reactive oxygen species (ROS) play crucial roles in early synaptic perturbations and neuropathology that drive memory deficits in Alzheimer's disease (AD). We recently showed that solubilized human amyloid beta peptide 1-42 (hAß1-42) causes rapid alterati ...

Article GUID: 36275011


The effects of napping on night-time sleep in healthy young adults

Author(s): Melodee Mograss

The discrepancies in the effects of napping on sleep quality may be due to differences in methodologies, napping behaviours, and daytime activity levels across studies. We determined whether napping behaviours and daytime activity levels are associated with night-time sleep fragmentation and sleep quality in young adults. A total of 62 healthy adults (mea ...

Article GUID: 35253300


G protein-coupled estrogen receptor-1 enhances excitatory synaptic responses in the entorhinal cortex

Author(s): Batallán Burrowes AA; Sundarakrishnan A; Bouhour C; Chapman CA;

Activation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory and associational input to the hippocampus, but it is unclear whether either estrogens or progestogens ...

Article GUID: 34399010


Are the Allergic Reactions of COVID-19 Vaccines Caused by mRNA Constructs or Nanocarriers? Immunological Insights

Author(s): Selvaraj G; Kaliamurthi S; Peslherbe GH; Wei DQ;

The Food and Drug Administration (FDA) has recently authorized the two messenger RNA (mRNA) vaccines BNT162b2 and mRNA-1273 for emergency use against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the COVID-19 coronavirus disease. BNT162b2 and mRNA-1273 vaccines were developed by Pfizer-BioNTech and Moderna, respectively, in 2020 ...

Article GUID: 34021862


Neurobehavioral, neurochemical and synaptic plasticity perturbations during postnatal life of rats exposed to chloroquine in-utero

Author(s): Olajide OJ; Alliy ZO; Ojo DO; Osinubi OO; Bello SO; Ibrahim FE; Adukwu FO; Abikoye TO; Gbadamosi IT; Mutholib NY; Bamisi O; Ajiboye OJ; Okesina AA; Alli-Oluwafuyi A; Oyewole AL; Nafiu AB; Akinola O;

Despite reports that quinoline antimalarials including chloroquine (Chq) exhibit idiosyncratic neuropsychiatric effects even at low doses, the drug continues to be in widespread use during pregnancy. Surprisingly, very few studies have examined the potential neurotoxic action of Chq exposure at d ...

Article GUID: 33845156


Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Author(s): Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Cell Rep. 2020 Jun 30;31(13):107838 Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Article GUID: 32610139


Exercising before a nap benefits memory better than napping or exercising alone.

Author(s): Mograss M, Crosetta M, Abi-Jaoude J, Frolova E, Robertson E, Pepin V, Dang-Vu TT

Sleep. 2020 Apr 01;: Authors: Mograss M, Crosetta M, Abi-Jaoude J, Frolova E, Robertson E, Pepin V, Dang-Vu TT

Article GUID: 32236442


Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.

Author(s): Sparks DW, Chapman CA

J Neurophysiol. 2016 08 01;116(2):658-70 Authors: Sparks DW, Chapman CA

Article GUID: 27146979


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