Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Microglial cells, or brain immune cells, are highly dynamic and continuously migrate in pathophysiological conditions. Their adhesion, as a physical characteristic, plays a key role in migration. In this study, we presented a microfluidic chip combination o ...

Article GUID: 39203655

Author(s): Ahmadi F; Tran H; Letourneau N; Little SR; Fortin A; Moraitis AN; Shih SCC;

Monoclonal antibody (mAb) discovery plays a prominent role in diagnostic and therapeutic applications. Droplet microfluidics has become a standard technology for high-throughput screening of antibody-producing cells due to high droplet single-cell confineme ...

Article GUID: 38441226

Author(s): Jager K; Orozco-Hidalgo MT; Springstein BL; Joly-Smith E; Papazotos F; McDonough E; Fleming E; McCallum G; Yuan AH; Hilfinger A; Hochschild ...

Prions are self-propagating protein aggregates formed by specific proteins that can adopt alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform encephalopathi ...

Article GUID: 37738299

Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Microglia cells, as the resident immune cells of the central nervous system (CNS), are highly motile and migratory in development and pathophysiological conditions. During their migration, microglia cells interact with their surroundings based on the variou ...

Article GUID: 36832056

Author(s): Kékedy-Nagy L; Perry JM; Little SR; Llorens OY; Shih SCC;

We present a novel "on-off", cost-effective, rapid electrochemical aptasensor combined with a microfluidics cartridge system for the detection of ?9-THC (?9-tetrahydrocannabinol) in human saliva via differential pulse voltammetry. The assay relied on the co ...

Article GUID: 36549107

Author(s): Allard P; Papazotos F; Potvin-Trottier L;

Cells are inherently dynamic, whether they are responding to environmental conditions or simply at equilibrium, with biomolecules constantly being made and destroyed. Due to their small volumes, the chemical reactions inside cells are stochastic, such that ...

Article GUID: 36312536

Author(s): Pou KRJ; Raghavan V; Packirisamy M;

The increasing trend in ensuring safe and quality foods necessitates the monitoring of food products throughout the food supply chain. Food packaging is an indispensable process as it provides various functions such as containment, protection, convenience, ...

Article GUID: 36192908

Author(s): Raju D; Bathini S; Badilescu S; Ghosh A; Packirisamy M;

Extracellular vesicles (EVs) are a group of communication organelles enclosed by a phospholipid bilayer, secreted by all types of cells. The size of these vesicles ranges from 30 to 1000 nm, and they contain a myriad of compounds such as RNA, DNA, proteins, ...

Article GUID: 35630197

Author(s): López RR; Sánchez LM; Alazzam A; Burnier JV; Stiharu I; Nerguizian V;

The shape and dimensions of a micromixer are key elements in the mixing process. Accurately quantifying the mixing efficiency enables the evaluation of the performance of a micromixer and the selection of the most suitable one for specific applications. In ...

Article GUID: 34577745

Author(s): Bathini S; Pakkiriswami S; Ouellette RJ; Ghosh A; Packirisamy M;

Extracellular vesicles (EVs) are the cell-derived vesicles which play a critical role in cell-to-cell communication, and disease progression. These vesicles contain a myriad of substances like RNA, DNA, proteins, and lipids from their origin cells, offering ...

Article GUID: 34517262

Author(s): Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of ...

Article GUID: 33455300