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Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats

Author(s): Meyer C; Schoettner K; Amir S;

Circadian dysfunction caused by exposure to aberrant light-dark conditions is associated with abnormal alcohol consumption in humans and animal models. Changes in drinking behavior have been linked to alterations in clock gene expression in reward-related brain areas, which could be attributed to either the effect of chronodisruption or alcohol. To date, ...

Article GUID: 39624490


Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus

Author(s): Plissonneau C; Santosa S;

The excessive accumulation of adipose tissue in obesity appears to result in adipose tissue dysfunction perpetuating the onset of obesity-related diseases, including type 2 diabetes (T2DM). In humans, adipose tissue is stored in several depots including subcutaneous and visceral. These depots contribute to the pathology of obesity differently owing to dif ...

Article GUID: 39553621


Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium

Author(s): Bamisi O; Oluwalabani AO; Arogundade TT; Olajide OJ;

Although there have been reports indicating that Datura Stramonium (D. stramonium) may induce anticholinergic and neuropsychiatry effects, the compound is still being used for recreational and medicinal purposes while ingestion during pregnancy has been documented. Intriguingly, minimal studies have investigated the potential neurotoxic impact of D. stram ...

Article GUID: 39303770


Cancer anorexia-cachexia syndrome is characterized by more than one inflammatory pathway

Author(s): Bruno Gagnon

CONCLUSIONS: This exploratory study identified three distinct pathways of inflammation, or lack thereof, characterizing different CACS phenotypes.

Article GUID: 38481033


Editorial: Neuroepigenetics and biological mechanisms of stress-induced socio-cognitive changes

Author(s): Daniels WMU; Ajonijebu DC; Olajide OJ;

No abstract available

Article GUID: 38445046


Changes in Purpose in Life and Low-Grade Chronic Inflammation Across Older Adulthood

Author(s): Giannis I; Wrosch C; Herriot H; Gouin JP;

ackground: Older adults often experience an increase in low-grade chronic inflammation. Purpose in life could act as a protective factor as it is associated with beneficial health outcomes. Purpose in life may exert part of its adaptive function by promoting persistence in goal pursuit. During older adulthood, however, when many individuals experience an ...

Article GUID: 37643057


Efficacy of topical versus oral analgesic medication compared to a placebo in injured athletes: A systematic review with meta-analysis

Author(s): Nudo S; Jimenez-Garcia JA; Dover G;

Background: Athletes are injured frequently and often take analgesic medication. Moreover, athletes commonly use non-prescription topical and oral medications with little guidance. Despite wide use, relatively few studies exist on the efficacy of pain medication in injured athletes compared to a placebo. Objective: To determine efficacy of topical or ora ...

Article GUID: 37278322


Immunoinflammatory processes: Overlapping mechanisms between obesity and eating disorders?

Author(s): Breton E; Fotso Soh J; Booij L;

Obesity and eating disorders are conditions that involve eating behaviors and are sometimes comorbid. Current evidence supports alterations in immunoinflammatory processes in both obesity and eating disorders. A plausible hypothesis is that immunoinflammatory processes may be involved in the pathophysiology of obesity and eating disorders. The aim of this ...

Article GUID: 35594735


Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates

Author(s): Cossette C; Chourey S; Ye Q; Reddy CN; Wang R; Poulet S; Slobodchikova I; Vuckovic D; Rokach J; Powell WS;

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is the only product of the proinflammatory 5-lipoxygenase pathway with potent chemoattractant effects for human eosinophils, suggesting an important role in eosinophilic diseases such as asthma. 5-Oxo-ETE, acting through its selective OXE receptor ...

Article GUID: 35158054


Altered immunometabolism in adipose tissue: a major contributor to the ageing process?

Author(s): Delaney KZ; Gillespie ZE; Murphy J; Wang C;

No abstract

Article GUID: 34159597


Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids

Author(s): Turner L; Santosa S;

With increasing adiposity in obesity, adipose tissue macrophages contribute to adipose tissue malfunction and increased circulating proinflammatory cytokines. The chronic low-grade inflammation that occurs in obesity ultimately gives rise to a state of metainflammation that increases the risk of metabolic disease. To date, only lifestyle and surgical inte ...

Article GUID: 33979430


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