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Hypothalamic-pituitary-adrenal axis functioning in offspring of parents with a major affective disorder: a meta-analytic review

Author(s): Serravalle L; Trespalacios F; Ellenbogen MA;

Because the offspring of parents with an affective disorder (OAD) are at high risk for developing mental disorders, and persons with an affective disorder (AD) show dysfunctional hypothalamic-pituitary-adrenal (HPA) axis activity, changes in HPA functioning in OAD might be an etiological risk factor that precedes the development of ADs. The primary aim of ...

Article GUID: 39207496


The perceived social support of parents having bipolar disorder impacts their children's mental health: a 10-year longitudinal study

Author(s): Trespalacios F; Boyle A; Serravalle L; Hodgins S; Ellenbogen MA;

Background: The offspring of parents with bipolar disorder (OBD) are at higher risk of developing psychopathology than the offspring of parents with no affective disorder (control). In addition to genetic predisposition, childhood adversity and a stressful family environment are important risk factors for the OBD. Protective factors in parents, such as so ...

Article GUID: 39066987


Improved Parent-Child Interactions Predict Reduced Internalizing Symptoms Among the Offspring of Parents with Bipolar Disorder Undergoing a Prevention Program: A Proof-of-Concept Study

Author(s): Serravalle L; Iacono V; Wilson AL; Orlando MA; Tsekova V; Ellenbogen MA;

The offspring of parents with bipolar disorder (OBD) exhibit elevated rates of psychopathology. However, preventative interventions are lacking. Using a quasi-experimental design with an assessment-only control group, we examined if a 12-week program (entitled Reducing Unwanted Stress in the Home, RUSH) decreases internalizing and externalizing symptoms i ...

Article GUID: 33544277


Early parent-child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16-year prospective cohort study.

Author(s): Doucette S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A

Early Interv Psychiatry. 2016 10;10(5):381-9 Authors: Doucette S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A

Article GUID: 25356767


Early exposure to parental bipolar disorder and risk of mood disorder: the Flourish Canadian prospective offspring cohort study.

Author(s): Goodday S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A

Early Interv Psychiatry. 2018 04;12(2):160-168 Authors: Goodday S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A

Article GUID: 26486425


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