Author(s): Borges C; Darecka A; Mainville-Berthiaume A; Ah-Yen E; Darvishmolla M; Courtemanche R; Shalev U;

Abstinence from drug use is often the result of the associated negative consequences. However, relapse occurs in a large proportion of abstinent users, and the underlying brain mechanisms are not clear. An arguably relevant brain area is the posterior paraventricular nucleus of the thalamus (pPVT ...

Article GUID: 41506524

Author(s): Leyton M; Nikolic M;

No abstract available

Article GUID: 38129315

Author(s): Firas Sedki

Food restriction augments drug seeking in abstinent rats. The underlying motivational mechanisms, however, remain unclear. We hypothesized that caloric restriction enhances the incentive value attributed to drug-associated cues and, in turn, augments drug seeking. Male rats were trained to lever-press for heroin, and then moved to the animal colony for a ...

Article GUID: 37714221

Author(s): Borges C; Inigo F; Quteishat N; Charles J; Ah-Yen E; U S;

Rational: Stress is a major trigger for drug relapse in humans and animal models, even after prolonged abstinence. However, animal models for stress-induced relapse were criticized for the lack of predictive and face validity.
Objectives: Here we investigated the effect of acute food deprivation stress in a novel str ...

Article GUID: 35951079

Author(s): D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES: We investigated the role of leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restrictio ...

Article GUID: 31811350