Reset filters

Search publications


Search by keyword
List by department / centre / faculty

No publications found.

 

The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans

Author(s): Shrivastava M; Kouyoumdjian GS; Kirbizakis E; Ruiz D; Henry M; Vincent AT; Sellam A; Whiteway M;

Transcription factors (TFs) play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans. We found that activation of the transcription factor C4_02500C_A (Adr1) conferred significant resistance against fluconazole. In Saccharomy ...

Article GUID: 37791798


Utilization of ferulic acid in Aspergillus niger requires the transcription factor FarA and a newly identified Far-like protein (FarD) that lacks the canonical Zn(II)2Cys6 domain

Author(s): Arentshorst M; Reijngoud J; van Tol DJC; Reid ID; Arendsen Y; Pel HJ; van Peij NNME; Visser J; Punt PJ; Tsang A; Ram AFJ;

The feruloyl esterase B gene (faeB) is specifically induced by hydroxycinnamic acids (e.g. ferulic acid, caffeic acid and coumaric acid) but the transcriptional regulation network involved in faeB induction and ferulic acid metabolism has only been partially addressed. To identify transcription f ...

Article GUID: 37746181


Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids

Author(s): Turner L; Santosa S;

With increasing adiposity in obesity, adipose tissue macrophages contribute to adipose tissue malfunction and increased circulating proinflammatory cytokines. The chronic low-grade inflammation that occurs in obesity ultimately gives rise to a state of metainflammation that increases the risk of metabolic disease. To date, only lifestyle and surgical inte ...

Article GUID: 33979430


Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity

Author(s): Wang C; Murphy J; Delaney KZ; Khor N; Morais JA; Tsoukas MA; Lowry DE; Mutch DM; Santosa S;

Fatty acid desaturase 1 (FADS1) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between FADS1 variants and SAT inflammatory status. To advance this area, we conducted an exploratory study ...

Article GUID: 33595419


The Relationship Between Cognitive Status and Known Single Nucleotide Polymorphisms in Age-Related Macular Degeneration.

Author(s): Murphy C; Johnson AP; Koenekoop RK; Seiple W; Overbury O;

Recent literature has reported a higher occurrence of cognitive impairment among individuals with Age-related Macular Degeneration (AMD) compared to older adults with normal vision. This pilot study explored potential links between single nucleotide polymorphisms (SNPs) in AMD and cognitive status. Individuals with AMD (N = 21) and controls (N = 18) were ...

Article GUID: 33178008


Processing High-Solid and High-Ammonia Rich Manures in a Two-Stage (Liquid-Solid) Low-Temperature Anaerobic Digestion Process: Start-Up and Operating Strategies.

Author(s): Mahato P, Goyette B, Rahaman MS, Rajagopal R

Bioengineering (Basel). 2020 Jul 25;7(3): Authors: Mahato P, Goyette B, Rahaman MS, Rajagopal R

Article GUID: 32722477


Arachidonic acid status negatively associates with forearm bone outcomes and glucose homeostasis in children with an overweight condition or obesity.

Author(s): Mak IL; Cohen TR; Vanstone CA; Weiler HA;

Long-chain polyunsaturated fatty acids are implicated in musculoskeletal health in adults. This study examined whether fatty acid status relates to bone health outcomes in children with overweight condition or obesity (body mass index z score, 3.1 ± 0.1; age, 9.0 ± 0.2 years; n = 108). Nondominant forearm bone density (distal one-third), geometry (4% site ...

Article GUID: 31269410


The Sexual Dimorphism of Lipid Kinetics in Humans.

Author(s): Santosa S, Jensen MD

Front Endocrinol (Lausanne). 2015;6:103 Authors: Santosa S, Jensen MD

Article GUID: 26191040


-   Page 1 / 1   -