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Augmenting glutamatergic, but not dopaminergic, activity in the nucleus accumbens shell disrupts responding to a discrete alcohol cue in an alcohol context

Author(s): Valyear MD; Brown A; Deyab G; Villaruel FR; Lahlou S; Caporicci-Dinucci N; Chaudhri N;

Discrete alcohol cues and contexts are relapse triggers for people with alcohol use disorder exerting particularly powerful control over behaviour when they co-occur. Here, we investigated the neural substrates subserving the capacity for alcohol-associated contexts to elevate responding to an alcohol-predictive conditioned stimulus (CS). Specifically, ra ...

Article GUID: 38185906


Learning processes in relapse to alcohol use: lessons from animal models

Author(s): Valyear MD; LeCocq MR; Brown A; Villaruel FR; Segal D; Chaudhri N;

Rationale: Alcohol use is reliably preceded by discrete and contextual stimuli which, through diverse learning processes, acquire the capacity to promote alcohol use and relapse to alcohol use. Objective: We review contemporary extinction, renewal, reinstatement, occasion setting, and sex differences research within a conditioning framework of relapse to ...

Article GUID: 36264342


Assessing the regional biogenic methanol emission from spring wheat during the growing season: A Canadian case study

Author(s): Cai M; An C; Guy C; Lu C; Mafakheri F;

As a volatile organic compound existing in the atmosphere, methanol plays a key role in atmospheric chemistry due to its comparatively high abundance and long lifetime. Croplands are a significant source of biogenic methanol, but there is a lack of systematic assessment for the production and emission of methanol from crops in various phases. In this stud ...

Article GUID: 34182392


A Novel Freshwater to Marine Evolutionary Transition Revealed within Methylophilaceae Bacteria from the Arctic Ocean

Author(s): Ramachandran A; McLatchie S; Walsh DA;

Bacteria inhabiting polar oceans, particularly the Arctic Ocean, are less studied than those at lower latitudes. Discovering bacterial adaptations to Arctic Ocean conditions is essential for understanding responses to the accelerated environmental changes occurring in the North. The Methylophilaceae are emerging as a model for investigating the genomic ba ...

Article GUID: 34154421


Context controls the timing of responses to an alcohol-predictive conditioned stimulus.

Author(s): Valyear MD, Chaudhri N

Behav Processes. 2020 Feb 01;:104061 Authors: Valyear MD, Chaudhri N

Article GUID: 32017964


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