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Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex

Author(s): Olajide OJ; Batallán Burrowes AA; da Silva IF; Bergdahl A; Chapman CA;

Reductions in circulating estrogens can contribute to cognitive decline, in part by impairing mitochondrial function within the hippocampal region. The entorhinal cortex provides the hippocampus with its main cortical input and, to assess the impact of estrogen deficiency on mitochondrial respiration and synaptic proteins in the entorhinal cortex, wildtyp ...

Article GUID: 39617168


The role of progesterone in memory bias during spatial navigation in females

Author(s): Eamonn L Gomez-Perales

Rats can use several memory systems to navigate a maze toward a reward. Two of these are place memory and response memory and female rats can be biased to predominantly use one over another. Both progesterone and estrogens have been shown to alter memory bias. Although the effects of estrogens have been well documented, the effects of progesterone remain ...

Article GUID: 36165431


G protein-coupled estrogen receptor-1 enhances excitatory synaptic responses in the entorhinal cortex

Author(s): Batallán Burrowes AA; Sundarakrishnan A; Bouhour C; Chapman CA;

Activation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory and associational input to the hippocampus, but it is unclear whether either estrogens or progestogens ...

Article GUID: 34399010


Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.

Author(s): Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Horm Behav. 2017 03;89:113-120 Authors: Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Article GUID: 28062232


17β-estradiol locally increases phasic dopamine release in the dorsal striatum.

Author(s): Shams WM, Cossette MP, Shizgal P, Brake WG

Neurosci Lett. 2018 02 05;665:29-32 Authors: Shams WM, Cossette MP, Shizgal P, Brake WG

Article GUID: 29175028


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