Author(s): Seralini GE; Jungers G; Andersen A; Antoniou M; Aschner M; Bacon MH; Bertrand M; Bohn T; Bonfleur ML; Bücking E; Defarge N; Djemil R; Domingo JL; Douzelet J; Fagan J; Fournier T; Garcia JLY; Gil S; Hervé-Gruyer P; Hilbeck A; Hilty L; Hub ...

We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petr ...

Article GUID: 41551494

Author(s): Sui J; Bi H; Yue R; Fu H; Yang A; An C;

Persistent oil contamination along coastlines can be treated by surface washing agents (SWAs), while low-temperature conditions can significantly impact the effectiveness of SWAs in oil removal. This study investigates the oil removal performance of a commercial SWA for oiled shoreline sand in cold-region environments. Batch oil removal tests were conduct ...

Article GUID: 41544565

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a sing ...

Article GUID: 41524627

Author(s): Su Y; Wang Z; Fu H; Yang A; Chen X; An C;

The 2023 wildfires caused serious riks to air quality and public health across various provinces in Canada, particularly during the period from May to June. This study aims to systematically evaluate the impact of the May-June wildfire events on air pollution in Canada using satellite Aerosol Optical Depth (AOD) data, along with the Hybrid Single-Particle ...

Article GUID: 41520990

Author(s): Spiegler P; Harirpoush A; Xiao Y;

Crucial in disease analysis and surgical planning, manual segmentation of volumetric medical scans (e.g. MRI, CT) is laborious, error-prone, and challenging to master, while fully automatic algorithms can benefit from user feedback. Therefore, with the complementary power of the latest radiological AI foundation models and virtual reality (VR)'s intui ...

Article GUID: 41509996

Author(s): Iuliano SG; Gagnon IJ; Iverson GL; Cook NE; Zemek R; Teel EF;

This secondary analysis examined the association between preexisting mental health conditions and clinical recovery trajectories in adolescents with concussion. Adolescents (13-17; n = 1238) completed clinical assessments (Post-Concussion Symptom Inventory [PCSI] =48 hours postinjury; PCSI/ Pediatric Quality of Life [PedsQL] for 3 months) and were categor ...

Article GUID: 41505351

Author(s): Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ;

Mutations in the TANGO2 gene are associated with a severe neurometabolic disorder in humans, often presenting with life-threatening metabolic crisis. However, the function of TANGO2 protein remains unknown. It has recently been proposed that TANGO2 transports heme within and between cells, from a ...

Article GUID: 41504601

Author(s): Moritz A; Ezzati M; Gélinas Y;

Iron hydroxides play a key role in the preservation of organic matter in soils and sediments, yet the specificity and extent of their interactions with lignin-derived phenols-important source indicators for terrestrial organic matter-remain poorly understood in aquatic systems. In this study, we analyzed surface and downcore sediments along the terrestria ...

Article GUID: 41500137

Author(s): Gheflati B; Mirzaei M; Zuhars J; Rottoo S; Rivaz H;

Purpose: Computer-assisted surgical navigation systems have been developed to improve the precision of total knee arthroplasty (TKA) by providing real-time guidance on implant alignment relative to patient anatomy. However, surface registration remains a key source of error that can propagate through the surgical workflow. This study investigates how pati ...

Article GUID: 41495592

Author(s): Yaghoobian S; An J; Jeong DW; Hwang JH;

Artificial intelligence (AI) and machine learning (ML) are increasingly integrated into Per- and polyfluoroalkyl substances (PFAS) research; however, the field remains fragmented with substantial variation in modeling objectives. This review provides one of the most comprehensive and detailed syntheses to date of AI/ML methods across the PFAS contaminatio ...

Article GUID: 41483514