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Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats

Author(s): Algallal HE; Laplante I; Casale D; Najafipashaki S; Pomerleau A; Paquette T; Samaha AN;

Rationale: Cocaine addiction is marked by high relapse rates, often triggered by drug-associated cues in the environment. These can be conditioned stimuli (CSs), which occur after drug intake and signal drug delivery, and discriminative stimuli (DSs), which signal that seeking responses will produce drug, before any such responses have been initiated (i.e ...

Article GUID: 41372546


Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues

Author(s): Ndiaye NA; Shamleh SA; Casale D; Castaneda-Ouellet S; Laplante I; Robinson MJF; Samaha AN;

Rationale: When people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include conditioned stimuli (CSs) signaling drug delivery and discriminative stimuli (DSs) signaling drug availability. Compared to CS effects, DS effects are ...

Article GUID: 38767684


Gut colonization by Proteobacteria alters host metabolism and modulates cocaine neurobehavioral responses

Author(s): Cuesta S; Burdisso P; Segev A; Kourrich S; Sperandio V;

Gut-microbiota membership is associated with diverse neuropsychological outcomes, including substance use disorders (SUDs). Here, we use mice colonized with Citrobacter rodentium or the human ?-Proteobacteria commensal Escherichia coli HS as a model to examine the mechanistic interactions between gut microbes and host responses to cocaine. We find that co ...

Article GUID: 36323315


Do stimulant medications produce sensitization in humans?

Author(s): Marco Leyton

No abstract

Article GUID: 35398453


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