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Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease

Author(s): Tremblay SA; Nathan Spreng R; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ;

Early detection of pathological changes in Alzheimer's disease (AD) has garnered significant attention in the last few decades as interventions aiming to prevent progression will likely be most effective when initiated early. White matter (WM) alterations are among the earliest changes in AD, ...

Article GUID: 40086421


Health behavior profiles in young survivors of childhood cancer: Findings from the St. Jude Lifetime Cohort Study

Author(s): Webster RT; Dhaduk R; Gordon ML; Partin RE; Kunin-Batson AS; Brinkman TM; Willard VW; Allen JM; Alberts NM; Lanctot JQ; Ehrhardt MJ; Li Z; Hudson MM; Robison LL; Ness KK;

Background: There is limited understanding of associations between a combination of health behaviors (physical activity, sedentary/screen-time, diet) and cardiometabolic health risk factors, physical performance, and emotional health among young (<18) childhood cancer survivor ...

Article GUID: 36943740


Body-composition phenotypes and their associations with cardiometabolic risks and health behaviours in a representative general US sample

Author(s): Kakinami L; Plummer S; Cohen TR; Santosa S; Murphy J;

Body mass index is poor at distinguishing between adiposity and muscle. Based on dual energy X-ray absorptiometry data, a diagnostic framework to analyze body composition by categorizing fat- and muscle-mass body composition into four phenotypes has been proposed. The objective of this study was to assess the association between body-composition phenotype ...

Article GUID: 36183799


Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Author(s): Goldfield GS; Walsh J; Sigal RJ; Kenny GP; Hadjiyannakis S; De Lisio M; Ngu M; Prud' homme D; Alberga AS; Doucette S; Goldfield DB; Cameron JD;

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is functionally related to BDNF, and is associated with obesity and metabolic complications in adults, but limited research exists among adolescents. This study comparatively examined carriers and non-carriers of the BDNF Val66Met ...

Article GUID: 34867148


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