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Characteristics and associated weight-loss responses to the diabetes prevention program for adults with acquired brain injury: secondary analysis of two randomized control trials

Authors: Quilico EAlrawi SCallender LMcShan EPark SBennett MDriver S


Affiliations

1 Baylor Scott & White Research Institute, Baylor Scott & White Health, Dallas, TX, USA; Applied Human Sciences, Concordia University, Montreal, QC, Canada. Electronic address: equilico@mgb.org.
2 Baylor Scott & White Research Institute, Baylor Scott & White Health, Dallas, TX, USA.

Description

Objective: Examine the association and temporal relationship between weight-loss and participant characteristics in a sample of community-dwelling adults with acquired brain injury (ABI), including cerebral vascular accident (CVA) and traumatic brain injury (TBI).

Design: Secondary data analysis of a wait-list control assessor-blinded randomized control trial (RCT) and parallel-group assessor-blinded RCT.

Setting: Community-based interventions through in-person and telehealth delivery.

Participants: 69 participants (45 CVA; 24 TBI) with 12-month follow-up assessments.

Interventions: The diabetes prevention program group lifestyle balance (DPP-GLB) program is a theoretically-grounded self-management intervention adapted for people with CVA (GLB-CVA) and TBI (GLB-TBI). Both interventions shared program goals of losing body weight through decreased caloric intake and increased physical activity (150 minutes/week).

Main outcome measures: Assessments for body weight completed at baseline, 3, 6, and 12 months, in addition to a range of biopsychosocial factors (demographic, injury-related, physiological, fitness-related, and self-reported outcomes).

Results: Race and private/public insurance had statistically significant associations with change in weight. Associations between baseline measures, biomarkers, walk scales, self-report outcomes, and corresponding weight change from baseline to 12-months showed a significant association for 6-minute walk test (6MWT). Regression analysis demonstrated variables with a P < .05, including 8-year diabetes risk (8YDR) and 6MWT showed a positive relationship with weight change.

Conclusions: Factors related to racial background and private/public insurance may correspond with weight-loss and further change after injury. Greater body weight associated with higher scores on 6MWT and/or 8YDR emphasize the need to examine associations between dimensions of fitness, diabetes predictors, and GLB outcomes.


Keywords: CVACerebrovascular AccidentDPPStrokeTBITraumatic Brain Injury


Links

PubMed: https://pubmed.ncbi.nlm.nih.gov/41610975/

DOI: 10.1016/j.apmr.2026.01.017