1 Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
2 Lady Davis Institute, Montreal, Quebec, Canada.
3 Department of Geriatric Medicine, Western University, London, Ontario, Canada.
4 Lawson Health Research Institute, London, Ontario, Canada.
5 Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
6 Sunnybrook Research Institute, Toronto, Ontario, Canada.
7 Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
8 Department of Neurosciences, University of California, San Diego, California, USA.
9 The Hotchkiss Brain Institute, Calgary, Alberta, Canada.
10 Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
11 McGill Center for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
12 Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
13 Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
14 Toronto Rehabilitation Institute, Toronto, Ontario, Canada.
15 Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
16 Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.
17 Department of Physiology and Pharmacology, Western University, London, Ontario, Canada.
18 Robarts Research, London, Ontario, Canada.
19 Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
20 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
21 Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada.
22 Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
23 Department of Psychiatry, Western University, London, Ontario, Canada.
24 McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, Canada.
25 McGill Centre for Integrative Neuroscience, Montreal, Quebec, Canada.
26 Department of Psychology, Concordia University, Montreal, Quebec, Canada.
27 Department of Medicine, McGill University, Montreal, Quebec, Canada.
28 Department of Psychology, University of Alberta, Edmonton, Alberta, Canada.
29 Department of Radiology, Laval University, Quebec City, Quebec, Canada.
30 Centre de recherche de l'Institut universitaire en santé mentale de Québec, Université Laval, Québec City, Québec, Canada.
31 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study.

Can J Neurol Sci. 2019 Jul 16;:1-13

Authors: Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Camicioli R, Smith EE, Fogarty J, Lindsay J, Best S, Evans A, Das S, Mohaddes Z, Pilon R, Poirier J, Phillips NA, MacNamara E, Dixon RA, Duchesne S, MacKenzie I, Rylett RJ

Abstract

BACKGROUND: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams.

METHODS: The COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.

RESULTS: The CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020.

CONCLUSION: Availability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years.

PMID: 31309917 [PubMed - as supplied by publisher]