1 Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
2 Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4; Concordia-PERFORM Centre, Concordia University, Montreal, Canada.

Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.

Appl Radiat Isot. 2017 Mar;121:76-81

Authors: Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A

Abstract

Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [11C]CO2 conversion into the highly reactive methylating agents [11C]CH3I and [11C]CH3OTf using automated modules relying on stationary valves. Here we describe development of the first in its kind "[11C]kit" for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses.

PMID: 28038410 [PubMed - indexed for MEDLINE]