Author(s): Rattray GF; Jourde HR; Baillet S; Coffey EBJ;

Subcortical brain regions like the thalamus are integral to numerous sensory and cognitive functions. Magnetoencephalography (MEG) enables the study of widespread brain networks with high temporal resolution, but the degree to which deep sources like the thalamus can be resolved remains unclear. Functional connectivity methods may enhance differentiation, ...

Article GUID: 41002111

Author(s): Jourde HR; Sobral M; Beltrame G; Coffey EBJ;

Sleep spindles are neural events unique to nonrapid eye movement sleep that play key roles in memory reactivation and consolidation. However, much of the evidence for their function remains correlational rather than causal. Closed-loop brain stimulation uses real-time monitoring of neural events (often via electroencephalography; EEG) to deliver precise a ...

Article GUID: 40626105

Author(s): Sobral M; Jourde HR; Marjani Bajestani SE; Coffey EBJ; Beltrame G;

Personalized closed-loop brain stimulation, in which algorithms used to detect neural events adapt to a user's unique neural characteristics, may be crucial to enable optimized and consistent stimulation quality for both fundamental research and clinical applications. Precise stimulation of sleep spindles-transient patterns of brain activity that occu ...

Article GUID: 40609549

Author(s): Cross N; O' Byrne J; Weiner OM; Giraud J; Perrault AA; Dang-Vu TT;

There is growing evidence in humans linking the temporal coupling between spindles and slow oscillations during NREM sleep with the overnight stabilization of memories encoded from daytime experiences in humans. However, whether the type and strength of learning influence that relationship is still unknown. Here we tested whether the amount or type of ver ...

Article GUID: 40214027

Author(s): Páez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbé F; Dang-Vu TT; Ripoll GP;

Introduction: Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset. Methods: Using data from a prospective cohort of mild to moderate AD (n = 60), we analyzed non-rapid eye moveme ...

Article GUID: 39878233

Author(s): Jourde HR; Coffey EBJ;

Sleep spindles are transient 11-16 Hz brain oscillations generated by thalamocortical circuits. Their role in memory consolidation is well established, but how they play a role in sleep continuity and protection of memory consolidation against interference is unclear. One theory posits that spindles or a neural refractory period following their offset act ...

Article GUID: 39588317

Author(s): Brown A; Gervais NJ; Gravelsins L; O' Byrne J; Calvo N; Ramana S; Shao Z; Bernardini M; Jacobson M; Rajah MN; Einstein G;

Bilateral salpingo-oophorectomy (BSO; removal of ovaries and fallopian tubes) prior to age 48 is associated with elevated risk for both Alzheimer's disease (AD) and sleep disorders such as insomnia and sleep apnea. In early midlife, individuals with BSO show reduced hippocampal volume, functi ...

Article GUID: 39178647

Author(s): Dang-Vu TT; Salimi A; Boucetta S; Wenzel K; O' Byrne J; Brandewinder M; Berthomier C; Gouin JP;

Background and aim: Predisposing factors place certain individuals at higher risk for insomnia, especially in the presence of precipitating conditions such as stressful life events. Sleep spindles have been shown to play an important role in the preservation of sleep continuity. Lower spindle den ...

Article GUID: 25713529

Author(s): Jourde HR; Merlo R; Brooks M; Rowe M; Coffey EBJ;

Closed-loop auditory stimulation (CLAS) is a brain modulation technique in which sounds are timed to enhance or disrupt endogenous neurophysiological events. CLAS of slow oscillation up-states in sleep is becoming a popular tool to study and enhance sleep's functions, as it increases slow oscillations, evokes sleep spindles and enhances memory consoli ...

Article GUID: 37675803

Author(s): Ozugergin I; Piekny A;

Cytokinesis is required to physically cleave a cell into two daughters at the end of mitosis. Decades of research have led to a comprehensive understanding of the core cytokinesis machinery and how it is regulated in animal cells, however this knowledge was generated using single cells cultured in vitro, or in early embryos before tissues develop. This ra ...

Article GUID: 36420142