Author(s): Yang Z; Chen Z; Xin Q; Lee K;

There is increasing concern over the environmental risks associated with deepwater petroleum exploration activities. The integration of environmental risk assessment and oil spill modeling can help to understand and quantitatively characterize the potential risks from subsea blowouts in specific regions. This study integrates a novel deepwater oil spill m ...

Article GUID: 39571296

Author(s): Fatoki TH; Balogun TC; Ojewuyi AE; Omole AC; Olukayode OV; Adewumi AP; Umesi AJ; Ijeoma NP; Apooyin AE; Chinedu CP; Idowu IE; Isah MJ;

Introduction: Oritavancin is a semi-synthetic lipoglycopeptide antibiotic primarily used to treat serious infections caused by Gram-positive bacteria. The aim of this study was to elucidate possible molecular targets of oritavancin in human and microbes in relevance to its mechanism of action and ...

Article GUID: 39439008

Author(s): Daniel A; Savary P; Foltête JC; Vuidel G; Faivre B; Garnier S; Khimoun A;

Modelling population connectivity is central to biodiversity conservation and often relies on resistance surfaces reflecting multi-generational gene flow. ResistanceGA (RGA) is a common optimization framework for parameterizing these surfaces by maximizing the fit between genetic distances and cost distances using maximum likelihood population effect mode ...

Article GUID: 39417711

Author(s): Khamsepour P; Moreau C; Dolatabadi A;

Nowadays, in the aerospace industry, additive manufacturing and repairing damaged metallic components like Ti6Al4V samples have grabbed attention. Among repairing techniques, solid-state additive manufacturing processes like cold spray are promising because of their unique benefits such as high deposition rate with almost no oxidation in the deposited mat ...

Article GUID: 38624932

Author(s): Hamidabad MN; Watson NA; Wright LN; Mansbach RA;

Antimicrobial peptides (AMPs) are of growing interest as potential candidates that may offer more resilience against antimicrobial resistance than traditional antibiotic agents. In this article, we perform the first in silico study of the synthetic ß sheet-forming AMP GL13K. Through atomistic simulations of single and multi-peptide systems under different ...

Article GUID: 38572930

Author(s): Sasikumar DSN; Thiruselvam P; Sundararajan V; Ravindran R; Gunasekaran S; Madathil D; Kaliamurthi S; Peslherbe GH; Selvaraj G; Sudhakaran SL;

Parkinson's disease (PD) is a complex neurological disease associated with the degeneration of dopaminergic neurons. Oxidative stress is a key player in instigating apoptosis in dopaminergic neurons. To improve the survival of neurons many dietary phytochemicals have gathered significant atte ...

Article GUID: 38460310

Author(s): Roshanfar M; Dargahi J; Hooshiar A;

The current study investigated the geometry optimization of a hybrid-driven (based on the combination of air pressure and tendon tension) soft robot for use in robot-assisted intra-bronchial intervention. Soft robots, made from compliant materials, have gained popularity for use in surgical interventions due to their dexterity and safety. The current stud ...

Article GUID: 38275456

Author(s): Jin Y; Fayyaz A; Liaqat A; Khan A; Alshammari A; Wang Y; Gu RX; Wei DQ;

Monkeypox Virus (MPXV) is a growing public health threat with increasing cases and fatalities globally. To date, no specific vaccine or small molecule therapeutic choices are available for the treatment of MPXV disease. In this work, we employed proteomics and structural vaccinology approaches to design mRNA and multi-epitopes-based vaccines (MVC) against ...

Article GUID: 37116237

Author(s): Nomura O; Sunohara M; Watanabe I; Itoh T;

The coronavirus disease 2019 (COVID-19) pandemic has challenged the feasibility of traditional in-person simulation-based clinical training due to the public health recommendation on social distancing. During the pandemic, telesimulation training was implemented to avoid multiple students and faculties gathering in confined spaces. While medical trainees& ...

Article GUID: 36670719

Author(s): Barone G; Buonomano A; Forzano C; Giuzio GF; Palombo A;

In the last years, the Covid-19 outbreak raised great awareness about ventilation system performance in confined spaces. Specifically, the heating, ventilation, and air conditioning system design and operating parameters, such as air change per hour, air recirculation ratio, filtration device performance, and vents location, play a crucial role in reducin ...

Article GUID: 35754761

Author(s): Maar M; McGregor L; Desjardins D; Delaney KZ; Bessette N; Reade M;

Clinical learning activities involving Indigenous patient actors that specifically address the development of culturally safe care skills among medical students are important in order to improve health care for Indigenous people. In 2020, the COVID-19 pandemic led to strict physical distancing regulations and regional lockdowns that made the in-person del ...

Article GUID: 35392591