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Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues

Author(s): Ndiaye NA; Shamleh SA; Casale D; Castaneda-Ouellet S; Laplante I; Robinson MJF; Samaha AN;

Rationale: When people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include conditioned stimuli (CSs) signaling drug delivery and discriminative stimuli (DSs) signaling drug availability. Compared to CS effects, DS effects are ...

Article GUID: 38767684


Modulation of cue value and the augmentation of heroin seeking in chronically food-restricted male rats under withdrawal

Author(s): Firas Sedki

Food restriction augments drug seeking in abstinent rats. The underlying motivational mechanisms, however, remain unclear. We hypothesized that caloric restriction enhances the incentive value attributed to drug-associated cues and, in turn, augments drug seeking. Male rats were trained to lever-press for heroin, and then moved to the animal colony for a ...

Article GUID: 37714221


Assessing the role of cortico-thalamic and thalamo-accumbens projections in the augmentation of heroin seeking in chronically food-restricted rats.

Author(s): Chisholm A; Rizzo D; Fortin É; Moman V; Quietshat N; Romano A; Capolicchio T; Shalev U;

Drug addiction is a chronic disorder characterized by compulsive drug seeking and involves repetitive cycles of compulsive drug use, abstinence, and relapse. In both human and animal models of addiction, chronic food restriction increases rates of relapse. Our laboratory has reported a robust increase in drug-seeking following a period of withdrawal in ch ...

Article GUID: 33219004


A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES: We investigated the role of leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restrictio ...

Article GUID: 31811350


Effects of contingent and noncontingent nicotine on lever pressing for liquids and consumption in water-deprived rats.

Author(s): Frenk H, Martin J, Vitouchanskaia C, Dar R, Shalev U

Eur J Pharmacol. 2017 Jan 05;794:224-233 Authors: Frenk H, Martin J, Vitouchanskaia C, Dar R, Shalev U

Article GUID: 27889434


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