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Asymmetric autocatalytic reactions and their stationary distribution

Author(s): Gallinger C; Popovic L;

We consider a general class of autocatalytic reactions, which has been shown to display stochastic switching behaviour (discreteness-induced transitions (DITs)) in some parameter regimes. This behaviour was shown to occur either when the overall species count is low or when the rate of inflow and outflow of species is relatively much smaller than the rate ...

Article GUID: 39679357


Study on the mechanism of regulating micromolar Fe utilization and promoting denitrification by guanosine monophosphate (GMP) based multi-signal functional material Hematin@Fe/GMP

Author(s): Hao Y; Guo T; Li H; Liu W; Chen Z; Wang X; Guo J;

A novel multi-signal functional material consisting of Hematin, Fe, and guanosine monophosphate (GMP) was successfully constructed (Hematin@Fe/GMP) to enhance denitrification efficiency based on the signal network regulation of electron transfer, micromolar Fe utilization, and microbial community. Hematin@Fe/GMP enhanced nitrate reduction rate by 2.33-fol ...

Article GUID: 39657473


Developmental heterogeneity of school burnout across the transition from upper secondary school to higher education: A 9-year follow-up study

Author(s): Nadon L; Morin AJS; Gilbert W; Olivier E; Salmela-Aro K;

This study utilized piecewise linear growth mixture analysis to examine the developmental heterogeneity of school burnout among a sample of 513 (67.6% females) Finnish students as they transitioned from upper secondary school to higher education (ages 17-25 years). Encompassing five measurement points (two before the transition and three after), our resul ...

Article GUID: 39645324


Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology

Author(s): Hrtonova V; Nejedly P; Travnicek V; Cimbalnik J; Matouskova B; Pail M; Peter-Derex L; Grova C; Gotman J; Halamek J; Jurak P; Brazdil M; Klimes P; Frauscher B;

Introduction: Precise localization of the epileptogenic zone is critical for successful epilepsy surgery. However, imbalanced datasets in terms of epileptic vs. normal electrode contacts and a lack of standardized evaluation guidelines hinder the consistent evaluation of automatic machine learnin ...

Article GUID: 39608298


Ion channel classification through machine learning and protein language model embeddings

Author(s): Ghazikhani H; Butler G;

Ion channels are critical membrane proteins that regulate ion flux across cellular membranes, influencing numerous biological functions. The resource-intensive nature of traditional wet lab experiments for ion channel identification has led to an increasing emphasis on computational techniques. This study extends our previous work on protein language mode ...

Article GUID: 39572876


The hockey fans in training intervention for men with overweight or obesity: a pragmatic cluster randomised trial

Author(s): Petrella RJ; Gill DP; Boa Sorte Silva NC; Riggin B; Blunt WM; Kfrerer M; Majoni M; Marsh J; Irwin JD; Stranges S; Zwarenstein M; Zou G;

Background: Obesity disproportionately impacts men's health yet fewer men engage in preventive healthcare. We examined the effectiveness of Hockey Fans in Training (Hockey FIT), a gender-sensitised lifestyle intervention that engages men with overweight/obesity through their passion as fans o ...

Article GUID: 39568632


Amorphous Cu/Fe nanoparticles with tandem intracellular and extracellular electron capacity for enhancing denitrification performance and recovery of co-contaminant suppressed denitrification

Author(s): Fu J; Guo T; Li H; Liu W; Chen Z; Wang X; Guo J;

In this study, a functionally stable insoluble Cu/Fe nanoparticles (Cu/Fe NPs) were synthesized and applied denitrification with different contaminants. The results showed that 50 mg/L Cu/Fe NPs increased NO3--N reduction rate up to 14.3 mg/(L·h) about 3 folds compared with the control system (4.7 mg/(L·h)), and Cu/Fe NPs exhibited excellent restorative e ...

Article GUID: 39542060


Immunomodulation of human T cells by microbubble-mediated focused ultrasound

Author(s): Baez A; Singh D; He S; Hajiaghayi M; Gholizadeh F; Darlington PJ; Helfield B;

While met with initial and ground-breaking success targeting blood borne cancers, cellular immunotherapy remains significantly hindered in the context of solid tumors by the tumor microenvironment. Focused ultrasound, in conjunction with microbubbles, has found tremendous potential as a targeted and local drug/gene delivery technique for cancer therapy. T ...

Article GUID: 39502696


Altered Amplitude of Low-Frequency Fluctuations of rs-fMRI Signal followed by rTMS Analgesic Effects in Non-Specific Chronic Low Back Pain (CLBP) Patients

Author(s): Masoumbeigi M; Riyahi Alam N; Kordi R; Rostami M; Rahimiforoushani A; Jafari AH; Hashemi H; Ebrahimpour A;

Background: Non-specific chronic low back pain (CLBP) is a common painful condition and is responsible for different physical disorders. Despite alternative therapies, patients still suffer from persistent pain. Repetitive transcranial magnetic stimulation (rTMS) has provided much evidence of pai ...

Article GUID: 39391282


Transcriptomics identify the triggering of citrate export as the key event caused by manganese deficiency in Aspergillus niger

Author(s): Fekete E; Bíró V; Márton A; Bakondi-Kovács I; Sándor E; Kovács B; Geoffrion N; Tsang A; Kubicek CP; Karaffa L;

For over a century, the filamentous Ascomycete fungus Aspergillus niger has played a pivotal role in the industrial production of citric acid. A critical fermentation parameter that sustains high-yield citric acid accumulation is the suboptimal concentration of manganese(II) ions in the culture b ...

Article GUID: 39377610


Update and validation of the Beliefs about Losing Control Inventory-II (BALCI-II): a psychometric investigation

Author(s): Kelly-Turner K; Radomsky AS;

The Beliefs about Losing Control Inventory (BALCI) was developed to assess negative beliefs about losing control in obsessive-compulsive disorder (OCD). Since its creation, research and theoretical work support negative beliefs about losing control as a potential transdiagnostic construct. The present study revised and expanded the original BALCI to be mo ...

Article GUID: 39373713


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