Author(s): McKay MJ; Weber KA; Wesselink EO; Smith ZA; Abbott R; Anderson DB; Ashton-James CE; Atyeo J; Beach AJ; Burns J; Clarke S; Collins NJ; Coppieters MW; Cornwall J; Crawford RJ; De Martino E; Dunn AG; Eyles JP; Feng HJ; Fortin M; Franettovic ...

Disorders affecting the neurological and musculoskeletal systems represent international health priorities. A significant impediment to progress in trials of new therapies is the absence of responsive, objective, and valid outcome measures sensitive to early disease changes. A key finding in indi ...

Article GUID: 39590726

Author(s): Tornblom A; Naghdi N; Rye M; Montpetit C; Fortin M;

Introduction: Exercise therapy is the primary endorsed form of conservative treatment for chronic low back pain (LBP). However, there is still conflicting evidence on which exercise intervention is best. While motor control exercise can lead to morphological and functional improvements of lumbar multifidus muscle in individuals with chronic LBP, the effec ...

Article GUID: 39258113

Author(s): Furno Puglia V; Paquette M; Bergdahl A;

Purpose: Peripheral responses might be important in handcycling, given the involvement of small muscles compared to other exercise modalities. Therefore, the goal of this study was to compare changes in muscle oxygen saturation (?SmO2) and deoxyhemoglobin level (?[HHb]) between different efforts and muscles. Methods: Handcyclists participated in a Wingat ...

Article GUID: 38856729

Author(s): Naghdi N; Elliott JM; Weber MH; Fehlings MG; Fortin M;

Study design: Cross-sectional study. Objectives: To examine the relationship between morphological changes of the deep extensor neck muscles in patients with degenerative cervical myelopathy (DCM) and the level of maximum spinal cord compression (MSCC) and canal compromise (MCC). A secondary objective was to examine the relationship between muscle morpho ...

Article GUID: 36289049

Author(s): Parenteau F; Puglia VF; Roberts M; Comtois AS; Bergdahl A;

Purpose: Cranberries have the highest polyphenol and antioxidant capacity among fruits and vegetables and may protect against exercise-induced free radical production, consequently improving performance. This study aimed to investigate the effect of polyphenol-rich cranberry extract (CE) on time-trial performance and lactate response following exercise. ...

Article GUID: 38297471

Author(s): Rosenstein B; Burdick J; Roussac A; Rye M; Naghdi N; Valentin S; Licka T; Sean M; Tétreault P; Elliott J; Fortin M;

It remains unclear whether paraspinal muscle fatty infiltration in low back pain (LBP) is i) solely intramuscular, ii) is lying outside the epimysium between the muscle and fascial plane (epimuscular) or iii) or combination of both, as imaging studies often use different segmentation protocols th ...

Article GUID: 38280825

Author(s): Ornowski J; Dziesinski L; Hess M; Krug R; Fortin M; Torres-Espin A; Majumdar S; Pedoia V; Bonnheim NB; Bailey JF;

Background: Paraspinal muscle fat infiltration is associated with spinal degeneration and low back pain, however, quantifying muscle fat using clinical magnetic resonance imaging (MRI) techniques continues to be a challenge. Advanced MRI techniques, including chemical-shift encoding (CSE) based w ...

Article GUID: 38222819

Author(s): Rosenstein B; Montpetit C; Vaillancourt N; Dover G; Khalini-Mahani N; Weiss C; Papula LA; Melek A; Fortin M;

Background: Low back pain (LBP) is one of the most disabling diseases and a major health issue. Despite the evidence of a link between paraspinal and gluteal muscle dysfunction and LBP, it is unknown whether aquatic exercises can lead to improvements in paraspinal and gluteal muscle morphology an ...

Article GUID: 38110922

Author(s): Naghdi N; Elliott JM; Weber MH; Fehlings MG; Fortin M;

Objectives: This study aimed to examine whether preoperative cervical muscle size, composition, and asymmetry from magnetic resonance imaging (MRI) can predict post-operative outcomes in patients with degenerative cervical myelopathy (DCM). Methods: A total of 171 patients with DCM were included. Relative total cross-sectional area (RCSA), functional CSA ...

Article GUID: 37745653

Author(s): Fortin M; Rye M; Roussac A; Montpetit C; Burdick J; Naghdi N; Rosenstein B; Bertrand C; Macedo LG; Elliott JM; Dover G; DeMont R; Weber MH; Pepin V;

Low back pain (LBP), a globally widespread and persistent musculoskeletal disorder, benefits from exercise therapy. However, it remains unclear which type leads to greater changes in paraspinal muscle health. This study aimed to (1) compare the effects of a combined motor control and isolated lum ...

Article GUID: 37762861

Author(s): Mansur A; Joseph R; Kim ES; Jean-Beltran PM; Udeshi ND; Pearce C; Jiang H; Iwase R; Milev MP; Almousa HA; McNamara E; Widrick J; Perez C; Ravenscroft G; Sacher M; Cole PA; Carr SA; Gupta VA;

Ubiquitin-proteasome system (UPS) dysfunction is associated with the pathology of a wide range of human diseases, including myopathies and muscular atrophy. However, the mechanistic understanding of specific components of the regulation of protein turnover during development and disease progressi ...

Article GUID: 37432316