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Ion channel classification through machine learning and protein language model embeddings

Author(s): Ghazikhani H; Butler G;

Ion channels are critical membrane proteins that regulate ion flux across cellular membranes, influencing numerous biological functions. The resource-intensive nature of traditional wet lab experiments for ion channel identification has led to an increasing emphasis on computational techniques. This study extends our previous work on protein language mode ...

Article GUID: 39572876


Quebec-based parents' concerns regarding their children's multilingual development

Author(s): Quirk E; Brouillard M; Ahooja A; Ballinger S; Polka L; Byers-Heinlein K; Kircher R;

Many parents express concerns for their children's multilingual development, yet little is known about the nature and strength of these concerns - especially among parents in multilingual societies. This pre-registered, questionnaire-based study addresses this gap by examining the concerns of 821 Quebec-based parents raising infants and toddlers aged ...

Article GUID: 39055771


Cross-modal plasticity in children with cochlear implant: converging evidence from EEG and functional near-infrared spectroscopy

Author(s): Deroche MLD; Wolfe J; Neumann S; Manning J; Hanna L; Towler W; Wilson C; Bien AG; Miller S; Schafer E; Gemignani J; Alemi R; Muthuraman M; Koirala N; Gracco VL;

Over the first years of life, the brain undergoes substantial organization in response to environmental stimulation. In a silent world, it may promote vision by (i) recruiting resources from the auditory cortex and (ii) making the visual cortex more efficient. It is unclear when such changes occu ...

Article GUID: 38846536


Language Exposure and Brain Myelination in Early Development

Author(s): Fibla L; Forbes SH; McCarthy J; Mee K; Magnotta V; Deoni S; Cameron D; Spencer JP;

The language environment to which children are exposed has an impact on later language abilities as well as on brain development; however, it is unclear how early such impacts emerge. This study investigates the effects of children's early language environment and socioeconomic status (SES) on brain structure in infancy at 6 and 30 months of age (both ...

Article GUID: 37188518


Thinking aloud: effects on text comprehension by children with specific language impairment and their peers

Author(s): McClintock B; Pesco D; Martin-Chang S;

Background: Many lines of evidence now suggest that inferencing plays a substantial role in text comprehension. However, inferencing appears to be difficult for children with language impairments, many of whom are also struggling readers. Aims: To assess the effects of a 'think-aloud' procedure on inference generation and narrative text comprehen ...

Article GUID: 25180778


Exploiting protein language models for the precise classification of ion channels and ion transporters

Author(s): Ghazikhani H; Butler G;

This study introduces TooT-PLM-ionCT, a comprehensive framework that consolidates three distinct systems, each meticulously tailored for one of the following tasks: distinguishing ion channels (ICs) from membrane proteins (MPs), segregating ion transporters (ITs) from MPs, and differentiating ICs from ITs. Drawing upon the strengths of six Protein Languag ...

Article GUID: 38656743


ALBA: a model-driven framework for the automatic generation of android location-based apps

Author(s): Gharaat M; Sharbaf M; Zamani B; Hamou-Lhadj A;

In recent years, the number of smartphone users has increased dramatically. These users download millions of apps and use them for various services. Due to the significant demand for mobile apps, developers often seek faster development methods and more effective tools and techniques to generate these apps. Many of these apps are location-based apps in wh ...

Article GUID: 38624616


Transcoding of French numbers for first- and second-language learners in third grade

Author(s): Lafay A; Adrien E; Lonardo Burr SD; Douglas H; Provost-Larocque K; Xu C; LeFevre JA; Maloney EA; Osana HP; Skwarchuk SL; Wylie J;

Transcoding is the process of translating between spoken and written numbers, and it is correlated with other mathematical skills. In the present study, we investigated the link between French number writing of 49 students in the third grade (aged 7-9 years) and their language skills. Transcoding ...

Article GUID: 37129448


Mixed-Language Input and Infant Volubility: Friend or Foe?

Author(s): Ruan Y; Byers-Heinlein K; Orena AJ; Polka L;

Language mixing is a common feature of many bilingually-raised children's input. Yet how it is related to their language development remains an open question. The current study investigated mixed-language input indexed by observed (30-second segment) counts and proportions in day-long recordings as well as parent-reported scores, in relation to infant ...

Article GUID: 38187471


Weighty words: exploring terminology about weight among samples of physicians, obesity specialists, and the general public

Author(s): Wilson OWA; Nutter S; Russell-Mayhew S; Ellard JH; Alberga AS; MacInnis CC;

Background: The words used to refer to weight and individuals with large bodies can be used to reinforce weight stigma. Given that most previous research has examined preferred terminology within homogenous groups, this research sought to examine terminology preferences across populations. Methods: This paper reports on data gathered with the general pub ...

Article GUID: 38131299


Enhanced identification of membrane transport proteins: a hybrid approach combining ProtBERT-BFD and convolutional neural networks

Author(s): Ghazikhani H; Butler G;

Transmembrane transport proteins (transporters) play a crucial role in the fundamental cellular processes of all organisms by facilitating the transport of hydrophilic substrates across hydrophobic membranes. Despite the availability of numerous membrane protein sequences, their structures and functions remain largely elusive. Recently, natural language p ...

Article GUID: 37497772


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