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In silico molecular targets, docking, dynamics simulation and physiologically based pharmacokinetics modeling of oritavancin

Author(s): Fatoki TH; Balogun TC; Ojewuyi AE; Omole AC; Olukayode OV; Adewumi AP; Umesi AJ; Ijeoma NP; Apooyin AE; Chinedu CP; Idowu IE; Isah MJ;

Introduction: Oritavancin is a semi-synthetic lipoglycopeptide antibiotic primarily used to treat serious infections caused by Gram-positive bacteria. The aim of this study was to elucidate possible molecular targets of oritavancin in human and microbes in relevance to its mechanism of action and ...

Article GUID: 39439008


Investigating the kinetics of marine and terrestrial organic carbon incorporation and degradation in coastal bulk sediment and water settings through isotopic lenses

Author(s): Mirzaei Y; Gélinas Y;

Coastal sediments are the main deposition center for allochthonous and autochthonous organic carbon (OC). The discharge of terrestrial biomass, anthropogenic activities, oceanic primary productivity, and natural events contribute to this carbon pool. The OC buried in sediments undergoes alteration through physical, biological and chemical processes, becom ...

Article GUID: 39117203


Bulk Free Radical Terpolymerization of Butyl Acrylate, 2-Methylene-1,3-Dioxepane and Vinyl Acetate: Terpolymer Reactivity Ratio Estimation

Author(s): Movafagh M; Meek KM; Scott AJ; Penlidis A; Dubé MA;

This investigation introduces the first estimation of ternary reactivity ratios for a butyl acrylate (BA), 2-methylene-1,3-dioxepane (MDO), and vinyl acetate (VAc) system at 50 °C, with an aim to develop biodegradable pressure-sensitive adhesives (PSAs). In this study, we applied the error-in-variables model (EVM) to estimate reactivity ratios. The ternar ...

Article GUID: 38794524


Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger

Author(s): Sgro M; Chow N; Olyaei F; Arentshorst M; Geoffrion N; Ram AFJ; Powlowski J; Tsang A;

Bacteria and fungi catabolize plant-derived aromatic compounds by funneling into one of seven dihydroxylated aromatic intermediates, which then undergo ring fission and conversion to TCA cycle intermediates. Two of these intermediates, protocatechuic acid and catechol, converge on ß-ketoadipate which is further cleaved to succinyl-CoA and acetyl-CoA. Thes ...

Article GUID: 37399977


Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions

Author(s): Godoy P; Darlington PJ; Whiteway M;

Candida albicans, an important fungal pathogen of humans, displays different morphologies, such as yeast, pseudo-hyphae and hyphae, which are recognized unequally by phagocytic cells of the innate immune response. Once C. albicans cells invade host tissues, immune cells such as macrophages are attracted to the site of infection and activated to recognize, ...

Article GUID: 35450285


Bioprinting of Adult Dorsal Root Ganglion (DRG) Neurons Using Laser-Induced Side Transfer (LIST)

Author(s): Roversi K; Ebrahimi Orimi H; Falchetti M; Lummertz da Rocha E; Talbot S; Boutopoulos C;

Cell bioprinting technologies aim to fabricate tissuelike constructs by delivering biomaterials layer-by-layer. Bioprinted constructs can reduce the use of animals in drug development and hold promise for addressing the shortage of organs for transplants. Here, we sought to validate the feasibility of bioprinting primary adult sensory neurons using a newl ...

Article GUID: 34442487


Effect of dissolved oxygen on simultaneous removal of ammonia, nitrate and phosphorus via biological aerated filter with sulfur and pyrite as composite fillers.

Author(s): Li Y, Guo J, Li H, Song Y, Chen Z, Lu C, Han Y, Hou Y

Bioresour Technol. 2019 Oct 28;296:122340 Authors: Li Y, Guo J, Li H, Song Y, Chen Z, Lu C, Han Y, Hou Y

Article GUID: 31704601


Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidβ aggregation, and lipid peroxidation.

Author(s): Seong SH, Ali MY, Jung HA, Choi JS

Bioorg Chem. 2019 Sep 18;92:103293 Authors: Seong SH, Ali MY, Jung HA, Choi JS

Article GUID: 31557622


Electro-demulsification of water-in-oil suspensions enhanced with implementing various additives.

Author(s): Taslimi Taleghani S, Fellah Jahromi A, Elektorowicz M

Chemosphere. 2019 May 20;233:157-163 Authors: Taslimi Taleghani S, Fellah Jahromi A, Elektorowicz M

Article GUID: 31173953


The effect of different divalent cations on the kinetics and fidelity of Bacillus stearothermophilus DNA polymerase.

Author(s): Vashishtha AK, Konigsberg WH

AIMS Biophys. 2018;5(2):125-143 Authors: Vashishtha AK, Konigsberg WH

Article GUID: 29888334


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