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Cell Fate Dynamics Reconstruction Identifies TPT1 and PTPRZ1 Feedback Loops as Master Regulators of Differentiation in Pediatric Glioblastoma-Immune Cell Networks

Author(s): Abicumaran Uthamacumaran

Pediatric glioblastoma is a complex dynamical disease that is difficult to treat due to its multiple adaptive behaviors driven largely by phenotypic plasticity. Integrated data science and network theory pipelines offer novel approaches to studying glioblas ...

Article GUID: 39420135


Recommendations on the use of artificial intelligence in health promotion

Author(s): Smith A; Arena R; Bacon SL; Faghy MA; Grazzi G; Raisi A; Vermeesch AL; Ong' wen M; Popovic D; Pronk NP; ...

The purpose of this perspective is to provide recommendations on the use of Artificial Intelligence (AI) in health promotion. To arrive at these recommendations, we followed a 6-step process. The f ...

Article GUID: 39389332


Transcriptomics identify the triggering of citrate export as the key event caused by manganese deficiency in Aspergillus niger

Author(s): Fekete E; Bíró V; Márton A; Bakondi-Kovács I; Sándor E; Kovács B; Geoffrion N; Tsang A; Kubicek CP; Karaffa L; ...

For over a century, the filamentous Ascomycete fungus Aspergillus niger has played a pivotal role in the industrial production of citric acid. A critical fermentation parameter that sustains high-y ...

Article GUID: 39377610


Education in Laparoscopic Cholecystectomy: Design and Feasibility Study of the LapBot Safe Chole Mobile Game

Author(s): Noroozi M; St John A; Masino C; Laplante S; Hunter J; Brudno M; Madani A; Kersten-Oertel M; ...

Background: Major bile duct injuries during laparoscopic cholecystectomy (LC), often stemming from errors in surgical judgment and visual misperception of critical anatomy, significantly impact mor ...

Article GUID: 39052314


LapBot-Safe Chole: validation of an artificial intelligence-powered mobile game app to teach safe cholecystectomy

Author(s): St John A; Khalid MU; Masino C; Noroozi M; Alseidi A; Hashimoto DA; Altieri M; Serrot F; Kersten-Oertal M; Madani A; ...

Background: Gaming can serve as an educational tool to allow trainees to practice surgical decision-making in a low-stakes environment. LapBot is a novel free interactive mobile game application th ...

Article GUID: 39009730


A Typology of National Park Co-management Agreements in the Era of Reconciliation in Canada

Author(s): Bruce K; Mulrennan ME;

Parks Canada, in response to commitments undertaken towards reconciliation, has signaled its readiness to reassess the participation of Indigenous peoples in the co-management of national parks, national park reserves, and national marine conservation areas ...

Article GUID: 38960921


Who Should Decide How Machines Make Morally Laden Decisions?

Author(s): Dominic Martin

Who should decide how a machine will decide what to do when it is driving a car, performing a medical procedure, or, more generally, when it is facing any kind of morally laden decision? More and more, machines are making complex decisions with a considerab ...

Article GUID: 27905083


A robust, low-temperature, closed-loop anaerobic system for high-solid mixed farm wastes: advancing agricultural waste management solutions in Canada

Author(s): Bele V; Goyette B; An C; Achouri IE; Chaib O; Rajagopal R;

This study investigates the effectiveness of low-temperature (20 ± 1 °C) anaerobic digestion (AD) for two organic multiple farm substrate combinations: Set 1 comprising chicken manure (CM), dairy manure (DM), and waste corn silage (CS) and Set 2 comprising ...

Article GUID: 38777978


Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains com ...

Article GUID: 38596311


Negative Affect and Drinking among Indigenous Youth: Disaggregating Within- and Between-Person Effects

Author(s): Ashley Reynolds

Negative affect (depression/anxiety) and alcohol use among Indigenous youth in Canada remain a concern for many communities. Disparate rates of these struggles are understood to be a potential outcome of colonization and subsequent intergenerational trauma ...

Article GUID: 38407776


The State of Artificial Intelligence in Skin Cancer Publications

Author(s): Joly-Chevrier M; Nguyen AX; Liang L; Lesko-Krleza M; Lefrançois P;

Background: Artificial intelligence (AI) in skin cancer is a promising research field to assist physicians and to provide support to patients remotely. Physicians' awareness to new developments in AI research is important to define the best practices an ...

Article GUID: 38323537


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