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Editorial: Insight in non-pharmacological treatment of pain-2023

Author(s): Geoffrey Dover

No abstract available

Article GUID: 39697557


In silico molecular targets, docking, dynamics simulation and physiologically based pharmacokinetics modeling of oritavancin

Author(s): Fatoki TH; Balogun TC; Ojewuyi AE; Omole AC; Olukayode OV; Adewumi AP; Umesi AJ; Ijeoma NP; Apooyin AE; Chinedu CP; Idowu IE; Isah MJ;

Introduction: Oritavancin is a semi-synthetic lipoglycopeptide antibiotic primarily used to treat serious infections caused by Gram-positive bacteria. The aim of this study was to elucidate possible molecular targets of oritavancin in human and microbes in relevance to its mechanism of action and ...

Article GUID: 39439008


Emerging hazardous chemicals and biological pollutants in Canadian aquatic systems and remediation approaches: A comprehensive status report

Author(s): Adeola AO; Paramo L; Fuoco G; Naccache R;

Emerging contaminants can be natural or synthetic materials, as well as materials of a chemical, or biological origin; these materials are typically not controlled or monitored in the environment. Canada is home to nearly 7 % of the world's renewable water supply and a wide range of different kinds of water systems, including the Great Lake, rivers, c ...

Article GUID: 39278485


Gambling Patterns and Problems of Gamblers on Licensed and Unlicensed Sites in France

Author(s): Costes JM; Kairouz S; Eroukmanoff V; Monson E;

In 2010 France enacted a law to regulate supply and consumption of online gambling. Its primary aim was to protect citizens from gambling-related harm. This study aims to assess differences in gambling patterns and related harm between online gamblers who use licensed versus unlicensed sites. Participants (N = 3860) completed a self-administered online su ...

Article GUID: 25862019


Insights into dietary phytochemicals targeting Parkinson's disease key genes and pathways: A network pharmacology approach

Author(s): Sasikumar DSN; Thiruselvam P; Sundararajan V; Ravindran R; Gunasekaran S; Madathil D; Kaliamurthi S; Peslherbe GH; Selvaraj G; Sudhakaran SL;

Parkinson's disease (PD) is a complex neurological disease associated with the degeneration of dopaminergic neurons. Oxidative stress is a key player in instigating apoptosis in dopaminergic neurons. To improve the survival of neurons many dietary phytochemicals have gathered significant atte ...

Article GUID: 38460310


Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms

Author(s): Pando-Naude V; Matthews TE; Højlund A; Jakobsen S; Østergaard K; Johnsen E; Garza-Villarreal EA; Witek MAG; Penhune V; Vuust P;

The pleasurable urge to move to music (PLUMM) activates motor and reward areas of the brain and is thought to be driven by predictive processes. Dopamine in motor and limbic networks is implicated in beat-based timing and music-induced pleasure, suggesting a central role of basal ganglia (BG) dop ...

Article GUID: 37724707


The Effects of Non-Pharmaceutical Interventions on COVID-19 Cases, Hospitalizations, and Mortality: A Systematic Literature Review and Meta-Analysis

Author(s): Peters JA; Farhadloo M;

Introduction: To assess the effects of various non-pharmaceutical interventions (NPI) on cases, hospitalizations, and mortality during the first wave of the COVID-19 pandemic. Methods: To empirically investigate the impacts of different NPIs on COVID-19-related health outcomes, a systematic literature review was conducted. We studied the effects of 10 NP ...

Article GUID: 37362389


Chronic pain in children and adolescents diagnosed with cancer: the challenge of mitigating the pain and the potential of integrating exercise into pain management

Author(s): Caru M; Alberts NM; Freeman MC; Dandekar SC; Rao P; McKeone DJ; Brown VI; McGregor LM; Schmitz KH;

Background: Pain is one of the most common and distressing symptoms experienced by children and adolescents diagnosed with cancer. It is vital that children and adolescents receive adequate pain management early on in their cancer treatments to mitigate pain and cancer-related symptoms. Exercise ...

Article GUID: 36952029


Toward a digital citizen lab for capturing data about alternative ways of self-managing chronic pain: An attitudinal user study

Author(s): Khalili-Mahani N; Woods S; Holowka EM; Pahayahay A; Roy M;

Background: Myriad psychosocial and cultural factors influence personal ways of coping with chronic pain (CP). Mobile health (mHealth) apps facilitate creation of citizen laboratories outside clinical frameworks. However, issues of safety, privacy and technostress must be addressed. This attitudinal user study aimed to assess whether persons with persiste ...

Article GUID: 36188996


Young people in Australia discuss strategies for preventing the normalisation of gambling and reducing gambling harm

Author(s): Pitt H; Thomas SL; Randle M; Cowlishaw S; Arnot G; Kairouz S; Daube M;

Background: The normalisation of gambling for young people has received considerable recent attention in the public health literature, particularly given the proliferation of gambling marketing aligned with sport. A range of studies and reports into the health and wellbeing of young people have recommended that they should be consulted and engaged in deve ...

Article GUID: 35549692


Do the Consequences Experienced by the People in the Life of a Problem Gambler Differ Based on the Nature of Their Relationship with the Gambler?

Author(s): Ferland F; Blanchette-Martin N; Côté M; Tremblay J; Kairouz S; Nadeau L; Savard AC; L' Espérance N; Dufour M;

Consequences experienced by the partners of individuals with a gambling disorder are well documented. However, little is known about the deleterious effects experienced by other people than partners of gamblers. A better understanding of these consequences could help improve clinical practices. T ...

Article GUID: 34286413


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