Author(s): Ruzzante DE; McCracken GR; Fraser DJ; MacMillan J; Buhariwalla C; Flemming JM;

Although efforts to estimate effective population size, census size and their ratio in wild populations are expanding, few empirical studies investigate interannual changes in these parameters. Hence, we do not know how repeatable or representative many estimates may be. Answering this question requires studies of long-term population dynamics. Here we to ...

Article GUID: 39582254

Author(s): Rezaei M; Liang M; Yalcin Z; Martin JH; Kazemi P; Bareke E; Ge ZJ; Fardaei M; Benadiva C; Hemida R; Hassan A; Maher GJ; Abdalla E; Buckett W; Bolze PA; Sandhu I; Duman O; Agrawal S; Qian J; Vallian Broojeni J; Bhati L; Miron P; Allias F; ...

To identify novel genes responsible for recurrent hydatidiform moles (HMs), we performed exome sequencing on 75 unrelated patients who were negative for mutations in the known genes. We identified biallelic deleterious variants in 6 genes, FOXL2, MAJIN, KASH5, SYCP2, MEIOB, and HFM1, in patients ...

Article GUID: 39545410

Author(s): Daniel A; Savary P; Foltête JC; Vuidel G; Faivre B; Garnier S; Khimoun A;

Modelling population connectivity is central to biodiversity conservation and often relies on resistance surfaces reflecting multi-generational gene flow. ResistanceGA (RGA) is a common optimization framework for parameterizing these surfaces by maximizing the fit between genetic distances and cost distances using maximum likelihood population effect mode ...

Article GUID: 39417711

Author(s): Clarke SH; Lawrence ER; Matte JM; Gallagher BK; Salisbury SJ; Michaelides SN; Koumrouyan R; Ruzzante DE; Grant JWA; Fraser DJ;

Effective population size (Ne) is a particularly useful metric for conservation as it affects genetic drift, inbreeding and adaptive potential within populations. Current guidelines recommend a minimum Ne of 50 and 500 to avoid short-term inbreeding and to preserve long-term adaptive potential re ...

Article GUID: 38613250

Author(s): Lawrence ER; Pedersen EJ; Fraser DJ;

The broad scale distribution of population-specific genetic diversity (GDP ) across taxa remains understudied relative to species diversity gradients, despite its relevance for systematic conservation planning. We used nuclear DNA data collected from 3678 vertebrate populations across the Americas to assess the role of environmental and spatial variables ...

Article GUID: 37365672

Author(s): Clarke SH; McCracken GR; Humphries S; Ruzzante DE; Grant JWA; Fraser DJ;

Sustainable management of exploited populations benefits from integrating demographic and genetic considerations into assessments, as both play a role in determining harvest yields and population persistence. This is especially important in populations subject to size-selective harvest, because size selective harvesting has the potential to result in sign ...

Article GUID: 36426123

Author(s): Quevedo Y; Booij L; Herrera L; Hernández C; Jiménez JP;

Genetic and early environmental factors are interwoven in the etiology of Borderline Personality Disorder (BPD). Epigenetic mechanisms offer the molecular machinery to adapt to environmental conditions. There are gaps in the knowledge about how epigenetic mechanisms are involved in the effects of early affective environment, development of BPD, and psycho ...

Article GUID: 36171872

Author(s): Azar N; Booij L;

Background: Prenatal maternal stress is increasingly recognized as a risk factor for offspring mental health challenges. DNA methylation may be a mechanism, but few studies directly tested mediation. These few integrative studies are reviewed along with studies from three research areas: prenatal maternal stress and child mental health, prenatal maternal ...

Article GUID: 36113690

Author(s): Schmidt C; Muñoz G; Lancaster LT; Lessard JP; Marske KA; Marshall KE; Garroway CJ;

Global biodiversity is organised into biogeographic regions that comprise distinct biotas. The contemporary factors maintaining differences in species composition between regions are poorly understood. Given evidence that populations with sufficient genetic variation can adapt to fill new habitats, it is surprising that more homogenisation of species asse ...

Article GUID: 35753949

Author(s): Steiger H; Booij L; Thaler L; St-Hilaire A; Israël M; Casey KF; Oliverio S; Crescenzi O; Lee V; Turecki G; Joober R; Szyf M; Breton É;

bjectives: Recent studies have reported altered methylation levels at disorder-relevant DNA sites in people who are ill with Anorexia Nervosa (AN) compared to findings in people with no eating disorder (ED) or in whom AN has remitted. The preceding implies state-related influences upon gene expre ...

Article GUID: 35703085

Author(s): Abicumaran Uthamacumaran

Cancers are complex dynamic ecosystems. Reductionist approaches to science are inadequate in characterizing their self-organized patterns and collective emergent behaviors. Since current approaches to single-cell analysis in cancer systems rely primarily on single time-point multiomics, many of the temporal features and causal adaptive behaviors in cancer ...

Article GUID: 35678918