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Combined effects of the contraceptive hormones, ethinyl estradiol and levonorgestrel, on the use of place and response memory in gonadally-intact female rats

Author(s): Lacasse JM; Boulos V; Fisher C; Hamilton S; Heron M; Mac Cionnaith CE; Peronace V; Tito N; Brake WG;

During maze navigation rats can rely on hippocampus-mediated place memory or striatum-mediated response memory. Ovarian hormones bias whether females use place or response memory to reach a reward. Here, we investigated the impact of the contraceptive hormones, ethinyl estradiol (EE) and levonorg ...

Article GUID: 36403510


Modeling hormonal contraception in female rats: a framework for studies in behavioral neurobiology

Author(s): Lacasse JM; Gomez-Perales E; Brake WG;

Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so is our understanding of the impact of HC on the brain and behavior. Here, we provide a review of the pharmacology of HC, as well as the methodology and best practices for designing a model of HC in female rats. We outline specific methodological considerations regard ...

Article GUID: 35952797


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