Author(s): Khademi S; Heidarian S; Afshar P; Mohammadi A; Sidiqi A; Nguyen ET; Ganeshan B; Oikonomou A;

In this study, we propose a novel hybrid framework for assessing the invasiveness of an in-house dataset of 114 pathologically proven lung adenocarcinomas presenting as subsolid nodules on Computed Tomography (CT). Nodules were classified into group 1 (G1), which included atypical adenomatous hyp ...

Article GUID: 41150036

Author(s): Mesaroli G; Olaizola S; Nair A; Nishat F; Pizzo A; Nathan PC; Alberts NM; Stinson JN;

Purpose: Neuropathic pain (NP) in individuals with cancer can arise from the cancer itself or its treatments. The prevalence of NP has been estimated in children living with cancer; however, the prevalence in adolescent survivorship is unknown. The aims of this study were to estimate the prevalence of NP among adolescent survivors of childhood cancer and ...

Article GUID: 40999274

Author(s): Alberts NM; Stratton KL; Leisenring WM; Pizzo A; Lamoureux É; Alschuler K; Flynn J; Krull KR; Jibb LA; Nathan PC; Olgin JE; Stinson JN; Armstrong GT;

Purpose: Intolerance of uncertainty is central to many psychological disorders and may contribute to pain. Despite the uncertainty inherent in childhood cancer survivorship, little is known about intolerance of uncertainty in this population. This study aimed to characterize intolerance of uncert ...

Article GUID: 40699439

Author(s): Neriya Hegade KP; Bhat RB; Packirisamy M;

Cancer diagnosis requires alternative techniques that allow for early, non-invasive, or minimally invasive identification. Traditional methods, like tissue biopsies, are highly invasive and can be traumatic for patients. Liquid biopsy, a less invasive option, detects cancer biomarkers in body fluids such as blood and urine. However, early-stage cancer oft ...

Article GUID: 40650129

Author(s): Vigano M; Kubal S; Habib S; Samarani S; Kasvis P; Koudieh N; Kilgour R; Farzin H; Ahmad A; Vigano A; Costiniuk CT;

Purpose: This study explored the effectiveness of cannabidiol (CBD) alone and in combination with multi-modal exercise (MME) to improve signs and symptoms of chemotherapy-induced peripheral neuropathy (CIPN), quality of life (QoL), and functional capacity in cancer survivors. Methods: Cancer sur ...

Article GUID: 40464985

Author(s): Klages KL; James RN; Kain ZN; Phipps S; Alberts NM; Fortier MA;

Introduction: Cancer pain remains a significant burden among children with cancer, and many patients experience pain starting around the time of diagnosis and throughout the course of treatment. A biopsychosocial treatment approach has been recommended to improve pain management in this population; however, specific psychosocial factors that contribute to ...

Article GUID: 40365620

Author(s): López RR; Ben El Khyat CZ; Chen Y; Tsering T; Dickinson K; Bustamante P; Erzingatzian A; Bartolomucci A; Ferrier ST; Douanne N; Mounier C; Stiharu I; Nerguizian V; Burnier JV;

Extracellular vesicles (EVs) are secreted by most cell types and play a central role in cell-cell communication. These naturally occurring nanoparticles have been particularly implicated in cancer, but EV heterogeneity and lengthy isolation methods with low yield make them difficult to study. To ...

Article GUID: 40069225

Author(s): Kavousi M; Saadatmand E; Masoumbeigi M; Mahdavi R; Riyahi Alam N;

Radiofrequency (RF) hyperthermia has been widely used for tumor ablation since magnetic-fluid-hyperthermia (MFH) can be utilized for increasing temperature in tumor-region as a complementary-method for hyperthermia. In this study, the effectiveness of using the magnetite-nanoparticles (Fe3O4) in RF hyperthermia for breast cancer (BC) treatment by determin ...

Article GUID: 39557504

Author(s): Baez A; Singh D; He S; Hajiaghayi M; Gholizadeh F; Darlington PJ; Helfield B;

While met with initial and ground-breaking success targeting blood borne cancers, cellular immunotherapy remains significantly hindered in the context of solid tumors by the tumor microenvironment. Focused ultrasound, in conjunction with microbubbles, has found tremendous potential as a targeted and local drug/gene delivery technique for cancer therapy. T ...

Article GUID: 39502696

Author(s): Jibb LA; Liu W; Stinson JN; Nathan PC; Chartrand J; Alberts NM; Hashemi E; Masama T; Pease HG; Torres LB; Cortes HG; Kuczynski S; Liu S; La H; Fortier MA;

Young children receiving outpatient cancer care are vulnerable to undermanaged pain. App-based solutions that provide pain treatment advice to parents in real-time and in all environments may improve access to quality pain care. We used a parent co-design approach involving iterative rounds of us ...

Article GUID: 39473834

Author(s): Abicumaran Uthamacumaran

Pediatric glioblastoma is a complex dynamical disease that is difficult to treat due to its multiple adaptive behaviors driven largely by phenotypic plasticity. Integrated data science and network theory pipelines offer novel approaches to studying glioblastoma cell fate dynamics, particularly phenotypic transitions over time. Here we used various single- ...

Article GUID: 39420135