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In silico molecular targets, docking, dynamics simulation and physiologically based pharmacokinetics modeling of oritavancin

Author(s): Fatoki TH; Balogun TC; Ojewuyi AE; Omole AC; Olukayode OV; Adewumi AP; Umesi AJ; Ijeoma NP; Apooyin AE; Chinedu CP; Idowu IE; Isah MJ;

Introduction: Oritavancin is a semi-synthetic lipoglycopeptide antibiotic primarily used to treat serious infections caused by Gram-positive bacteria. The aim of this study was to elucidate possible molecular targets of oritavancin in human and microbes in relevance to its mechanism of action and ...

Article GUID: 39439008


Deep neural network-based robotic visual servoing for satellite target tracking

Author(s): Ghiasvand S; Xie WF; Mohebbi A;

In response to the costly and error-prone manual satellite tracking on the International Space Station (ISS), this paper presents a deep neural network (DNN)-based robotic visual servoing solution to the automated tracking operation. This innovative approach directly addresses the critical issue of motion decoupling, which poses a significant challenge in ...

Article GUID: 39440297


Monitoring pilot trainees' cognitive control under a simulator-based training process with EEG microstate analysis

Author(s): Zhao M; Jia W; Jennings S; Law A; Bourgon A; Su C; Larose MH; Grenier H; Bowness D; Zeng Y;

The objective of pilot training is to equip trainees with the knowledge, judgment, and skills to maintain control of an aircraft and respond to critical flight tasks. The present research aims to investigate changes in trainees' cognitive control levels during a pilot training process while t ...

Article GUID: 39428425


Generalization limits of Graph Neural Networks in identity effects learning

Author(s): D' Inverno GA; Brugiapaglia S; Ravanelli M;

Graph Neural Networks (GNNs) have emerged as a powerful tool for data-driven learning on various graph domains. They are usually based on a message-passing mechanism and have gained increasing popularity for their intuitive formulation, which is closely linked to the Weisfeiler-Lehman (WL) test for graph isomorphism to which they have been proven equivale ...

Article GUID: 39426036


AAT4IRS: automated acceptance testing for industrial robotic systems

Author(s): Dos Santos MG; Hallé S; Petrillo F; Guéhéneuc YG;

Industrial robotic systems (IRS) consist of industrial robots that automate industrial processes. They accurately perform repetitive tasks, replacing or assisting with dangerous jobs like assembly in the automotive and chemical industries. Failures in these systems can be catastrophic, so it is important to ensure their quality and safety before using the ...

Article GUID: 39420929


Cell Fate Dynamics Reconstruction Identifies TPT1 and PTPRZ1 Feedback Loops as Master Regulators of Differentiation in Pediatric Glioblastoma-Immune Cell Networks

Author(s): Abicumaran Uthamacumaran

Pediatric glioblastoma is a complex dynamical disease that is difficult to treat due to its multiple adaptive behaviors driven largely by phenotypic plasticity. Integrated data science and network theory pipelines offer novel approaches to studying glioblastoma cell fate dynamics, particularly phenotypic transitions over time. Here we used various single- ...

Article GUID: 39420135


What can optimized cost distances based on genetic distances offer? A simulation study on the use and misuse of ResistanceGA

Author(s): Daniel A; Savary P; Foltête JC; Vuidel G; Faivre B; Garnier S; Khimoun A;

Modelling population connectivity is central to biodiversity conservation and often relies on resistance surfaces reflecting multi-generational gene flow. ResistanceGA (RGA) is a common optimization framework for parameterizing these surfaces by maximizing the fit between genetic distances and cost distances using maximum likelihood population effect mode ...

Article GUID: 39417711


The global distribution and drivers of wood density and their impact on forest carbon stocks

Author(s): Mo L; Crowther TW; Maynard DS; van den Hoogen J; Ma H; Bialic-Murphy L; Liang J; de-Miguel S; Nabuurs GJ; Reich PB; Phillips OL; Abegg M; Adou Yao YC; Alberti G; Almeyda Zambrano AM; Alvarado BV; Alvarez-Dávila E; Alvarez-Loayza P; Alves ...

The density of wood is a key indicator of the carbon investment strategies of trees, impacting productivity and carbon storage. Despite its importance, the global variation in wood density and its environmental controls remain poorly understood, preventing accurate predictions of global forest ca ...

Article GUID: 39406932


Topology optimization of adaptive sandwich plates with magnetorheological core layer for improved vibration attenuation

Author(s): Zare M; Sedaghati R;

In this study the optimum topology distribution of the magnetorheological elastomer (MRE) layer in an adaptive sandwich plate is investigated. The adaptive sandwich plate consists of an MR elastomer layer embedded between two thin elastic plates. A finite element model has been first formulated to derive the governing equations of motion. A design optimiz ...

Article GUID: 39398530


Altered Amplitude of Low-Frequency Fluctuations of rs-fMRI Signal followed by rTMS Analgesic Effects in Non-Specific Chronic Low Back Pain (CLBP) Patients

Author(s): Masoumbeigi M; Riyahi Alam N; Kordi R; Rostami M; Rahimiforoushani A; Jafari AH; Hashemi H; Ebrahimpour A;

Background: Non-specific chronic low back pain (CLBP) is a common painful condition and is responsible for different physical disorders. Despite alternative therapies, patients still suffer from persistent pain. Repetitive transcranial magnetic stimulation (rTMS) has provided much evidence of pai ...

Article GUID: 39391282


Recommendations on the use of artificial intelligence in health promotion

Author(s): Smith A; Arena R; Bacon SL; Faghy MA; Grazzi G; Raisi A; Vermeesch AL; Ong' wen M; Popovic D; Pronk NP;

The purpose of this perspective is to provide recommendations on the use of Artificial Intelligence (AI) in health promotion. To arrive at these recommendations, we followed a 6-step process. The first step was to recruit an international authorship team from the Healthy Living for Pandemic Event ...

Article GUID: 39389332


The degradation of polylactic acid face mask components in different environments

Author(s): Lyu L; Bagchi M; Ng KTW; Markoglou N; Chowdhury R; An C; Chen Z; Yang X;

The disposal of fossil fuel-based plastics poses a huge environmental challenge, leading to increased interest in biodegradable alternatives such as polylactic acid (PLA). This study focuses on the environmental impact and degradation of PLA face mask components under various conditions (UV (Ultraviolet) radiation, DI water, landfill leachate of various a ...

Article GUID: 39378804


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