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File-based localization of numerical perturbations in data analysis pipelines.

Author(s): Salari A, Kiar G, Lewis L, Evans AC, Glatard T

BACKGROUND: Data analysis pipelines are known to be affected by computational conditions, presumably owing to the creation and propagation of numerical errors. While this process could play a major role in the current reproducibility crisis, the precise causes of such instabilities and the path along which they propagate in pipelines are unclear. METHOD: ...

Article GUID: 33269388


Genome Sequence Resource of Bacillus velezensis EB14, a native endophytic bacterial strain with biocontrol potential against the poplar stem canker causative pathogen, Sphaerulina musiva.

Author(s): Naik S, Tsang A, Ramanan US, Dayanandan S

Bacillus velezensis EB14, isolated from a leaf of Populus ? jackii, possesses antagonistic activity against Sphaerulina musiva, a fungal pathogen of Populus sp. that causes leaf spots and stem cankers on Poplars limiting the utility of hybrid poplars as plantation trees. We sequenced the genome of B. velezensis EB14 to gain insights into the underlying ba ...

Article GUID: 33263425


Synthesis of 2,5-Diaryl Nonsymmetric Furans C6-Platform Chemicals via Catalytic Conversion of Biomass and the Formal Synthesis of Dantrolene.

Author(s): Chacón-Huete F, Lasso JD, Szavay P, Covone J, Forgione P

Biomass-derived commodity chemical 5-hydroxymethyl furfural is an underutilized C6-platform chemical derived from cellulose that is ideal to prepare next-generation value-added products. We have developed an efficient synthetic strategy to access 2,5-diaryl nonsymmetric furans from 5-hydroxymethyl furfural utilizing decarboxylative cross-couplings. A key ...

Article GUID: 33253575


Empirically Derived Profiles of Health-Related Quality of Life in Youth and Young Adults with Sickle Cell Disease.

Author(s): Keenan ME, Loew M, Berlin KS, Hodges J, Alberts NM, Hankins JS, Porter JS

OBJECTIVE: Determining how the health-related quality of life (HRQOL) is impacted by living with Sickle Cell Disease (SCD) can inform psychosocial interventions. The purpose of the present study is to determine if demographic and treatment variables predict membership into empirically derived subgroups of HRQOL among youth and young adults with SCD. METHO ...

Article GUID: 33249456


Source imaging of deep-brain activity using the regional spatiotemporal Kalman filter

Author(s): Hamid L; Habboush N; Stern P; Japaridze N; Aydin Ü; Wolters CH; Claussen JC; Heute U; Stephani U; Galka A; Siniatchkin M;

Background and objective: The human brain displays rich and complex patterns of interaction within and among brain networks that involve both cortical and subcortical brain regions. Due to the limited spatial resolution of surface electroencephalography (EEG), EEG source imaging is used to recons ...

Article GUID: 33250282


TMS and H1-MRS measures of excitation and inhibition following lorazepam administration.

Author(s): Ferland MC, Therrien-Blanchet JM, Proulx S, Klees-Themens G, Bacon BA, Vu TTD, Théoret H

This study aimed at better understanding the neurochemistry underlying TMS and MRS measurements as it pertains to GABAergic activity following administration of allosteric GABAA receptor agonist lorazepam. Seventeen healthy adults (8 females, 26.0 ± 5.4 years old) participated in a double-blind, crossover, placebo-controlled study, where participants unde ...

Article GUID: 33246064


Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.

Author(s): Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, ...

Article GUID: 33238462


Cerebellar Cortex 4-12 Hz Oscillations and Unit Phase Relation in the Awake Rat.

Author(s): Lévesque M; Gao H; Southward C; Langlois JMP; Léna C; Courtemanche R;

Oscillations in the granule cell layer (GCL) of the cerebellar cortex have been related to behavior and could facilitate communication with the cerebral cortex. These local field potential (LFP) oscillations, strong at 4-12 Hz in the rodent cerebellar cortex during awake immobility, should also be an indicator of an underlying influence on the patterns of ...

Article GUID: 33240052


Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.

Author(s): González Cautela BV; Quintana GR; Akerman J; Pfaus JG;

RATIONALE: Sexual side effects of chronic treatment with selective serotonin reuptake inhibitors (SSRIs) in humans include anorgasmia and loss of sexual desire and/or arousal which interferes with treatment compliance. There are few options at present to reduce these effects. Because orgasm and desire are mediated in part by activation of sympathetic arou ...

Article GUID: 33242109


Understanding the temporal evolution of COVID-19 research through machine learning and natural language processing.

Author(s): Ebadi A; Xi P; Tremblay S; Spencer B; Pall R; Wong A;

The outbreak of the novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been continuously affecting human lives and communities around the world in many ways, from cities under lockdown to new social experiences. Although in most cases COVID-19 results in mild illness, it has drawn glob ...

Article GUID: 33230352


Visual and haptic responses as measures of word comprehension and speed of processing in toddlers: Relative predictive utility.

Author(s): Smolak E; Hendrickson K; Zesiger P; Poulin-Dubois D; Friend M;

Early vocabulary knowledge and speed of word processing are important foundational skills for the development of preschool and school-age language and cognition. However, the variance in outcomes accounted for by parent-reported receptive or expressive vocabulary is generally modest. Recent research suggests that directly assessed, decontextualized vocabu ...

Article GUID: 33221662


The Epistemology of Evolutionary Psychology Offers a Rapprochement to Cultural Psychology

Author(s): Gad Saad

Many detractors of evolutionary psychology (EP) presume that adaptive arguments are nothing more than whimsical and unfalsifiable just-so stories. The reality though is that the epistemology of EP is precisely the opposite of this antiquated canard in that it fixes the evidentiary threshold much higher than is typically achieved by most scientists. EP ama ...

Article GUID: 33224071


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