Author(s): Ferraro S; de Zavalia N; Belforte N; Amir S;
Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterised by restrictive patterns of behaviour and alterations in social interaction and communication. Up to 80% of children with ASD exhibit sleep-wake cycle disturbances, emphasising the pressing need for novel approaches in the treatment of ASD-associated comorbidities. Whil ...
Article GUID: 34650409
Author(s): Munot P; McCrea N; Torelli S; Manzur A; Sewry C; Chambers D; Feng L; Ala P; Zaharieva I; Ragge N; Roper H; Marton T; Cox P; Milev MP; Liang WC; Maruyama S; Nishino I; Sacher M; Phadke R; Muntoni F;
Aims: TRAPPC11, a subunit of the transport protein particle (TRAPP) complex is important for complex integrity and anterograde membrane transport from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. Several individuals with TRAPPC11 mutations have been reported with muscl ...
Article GUID: 34648194
Author(s): Durairaj P; Venkatesan S; Narayanan V; Babu M;
Background: Idiopathic pulmonary fibrosis is characterized by progressive lung tissue remodeling and disproportionate deposition of collagenous proteins with limited therapeutic interventions. The purpose of this study was to determine whether curcumin inhibits bleomycin (BLM)-induced increases in synthesis, degradation and cross-linking of lung collagen ...
Article GUID: 34643929
Author(s): Gravel-Tatta L; DeWolf C; Badia A;
Nanoparticle carriers show promise for drug delivery, including by inhalation, where the first barrier for uptake in the lungs is the monolayer pulmonary surfactant membrane that coats the air/alveoli interface and is critical to breathing. It is imperative to establish the fate of potential nanocarriers and their effects on the biophysical properties of ...
Article GUID: 34644076
Author(s): Samadi S; Dargahi J; Narayanswamy S;
We report the design of a high-efficiency spectral-domain spectrometer with cylindrical optics for line scanning optical coherence tomography (OCT). The spectral nonlinearity in k space (wavenumber) lowers the depth-dependent signal sensitivity of the spectrometers. For linearizing, in this design, grating and prism have been introduced. For line scanning ...
Article GUID: 34640783
Author(s): Maïano C; Morin AJS; April J; Coutu S; Dugas C; Hue O;
This study examined whether profiles varying in actual and perceived locomotor and ball skill competencies would be identified and whether these profiles would differ in relation to children's characteristics. Participants were 127 (70 boys; 57 girls) French-speaking Canadian children (5-11 years). Actual and perceived motor competencies were, respect ...
Article GUID: 34636286
Author(s): Przybyszewski B; Kozera R; Krawczyk ZD; Boczkowska A; Dolatabadi A; Amer A; Sztorch B; Przekop RE;
Ice formation on the aerodynamic surfaces of an aircraft is regarded as a major problem in the aerospace industry. Ice accumulation may damage parts, sensors and controllers and alter the aerodynamics of the airplane, leading to a range of undesired consequences, including flight delays, emergenc ...
Article GUID: 34640083
Author(s): Legault-Denis C; Aghourian M; Soucy JP; Rosa-Neto P; Dagher A; Aumont E; Wickens R; Bedard MA;
Background: Severe cholinergic degeneration is known to occur in Parkinson's disease (PD) and is thought to play a primary role in the cognitive decline associated with this disease. Although cholinergic losses occur in all patients with PD, cognitive performance remains normal for many of th ...
Article GUID: 34628195
Author(s): Bayeh R; Yampolsky MA; Ryder AG;
Over the course of the year 2020, the global scientific community dedicated considerable effort to understanding COVID-19. In this review, we discuss some of the findings accumulated between the onset of the pandemic and the end of 2020, and argue that although COVID-19 is clearly a biological disease tied to a specific virus, the culture-mind relation at ...
Article GUID: 34630195
Author(s): Iriah SC; Borges C; Shalev U; Cai X; Madularu D; Kulkarni PP; Ferris CF;
Background: Maraviroc is an antiretroviral agent and C-C chemokine coreceptor 5 (CCR5) antagonist that is currently used to treat human immunodeficiency virus. CCR5/µ-opioid receptor heterodimerization suggests that maraviroc could be a treatment for oxycodone abuse. We treated rats with maraviroc to explore its effect on oxycodone-seekin ...
Article GUID: 34625487
Author(s): Geng X; Khalil CA; Prince RC; Lee K; An C; Boufadel MC;
The 2010 Deepwater Horizon (DWH) blowout released 3.19 million barrels (435 000 tons) of crude oil into the Gulf of Mexico. Driven by currents and wind, an estimated 22 000 tons of spilled oil were deposited onto the northeastern Gulf shorelines, adversely impacting the ecosystems and economies of the Gulf coast regions. In this work we present field work ...
Article GUID: 34617733
Author(s): Gilbert AC; Lee JG; Coulter K; Wolpert MA; Kousaie S; Gracco VL; Klein D; Titone D; Phillips NA; Baum SR;
Previous studies of word segmentation in a second language have yielded equivocal results. This is not surprising given the differences in the bilingual experience and proficiency of the participants and the varied experimental designs that have been used. The present study tried to account for a ...
Article GUID: 34603133
