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The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands

Author(s): Howland JG; Ito R; Lapish CC; Villaruel FR;

Emerging evidence implicates rodent medial prefrontal cortex (mPFC) in tasks requiring adaptation of behavior to changing information from external and internal sources. However, the computations within mPFC and subsequent outputs that determine behavior are incompletely understood. We review the involvement of mPFC subregions, and their projections to th ...

Article GUID: 35131398


Generation of oligonucleotide conjugates via one-pot diselenide-selenoester ligation-deselenization/alkylation

Author(s): Liczner C; Hanna CC; Payne RJ; Wilds CJ;

A breadth of strategies are needed to efficiently modify oligonucleotides with peptides or lipids to capitalize on their therapeutic and diagnostic potential, including the modulation of in vivo chemical stability and for applications in cell-targeting and cell-permeability. The chemical linkages typically used in peptide oligonucleotide conjugates (POCs) ...

Article GUID: 35126973


Bioinspired facilitation of intrinsically conductive polymers: Mediating intra/extracellular electron transfer and microbial metabolism in denitrification

Author(s): Guo T; Lu C; Chen Z; Song Y; Li H; Han Y; Hou Y; Zhong Y; Guo J;

Intrinsically conductive polymers, polyaniline and polyaniline sulfonate (PASAni) were used to explore their effect on denitrification. Denitrification was accelerated 1.90 times by 2 mM PASAni and the possible mechanisms were mainly attributed to the accelerated electron transfer and the enhanced microbial metabolism activity. Intracellular electron tran ...

Article GUID: 35124084


A regional numerical environmental multimedia modeling approach to assess spatial Eco-Environmental exposure risk of perfluorooctane sulfonate (PFOS) in the Pearl river basin

Author(s): Chen Z; Dong J; Asif Z;

This paper presents a novel numerical environmental multimedia modeling system (RNEMM) for assessing the environmental fate of emerging organic contaminants and their relative health risk at a regional scale. The RNEMM is developed based on an integrated numerical algorithm that comprises four sub-models: a river network simulation module, a gaseous phase ...

Article GUID: 35121494


Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women

Author(s): Gagne C; Piot A; Brake WG;

Ketamine has been shown to acutely and rapidly ameliorate depression symptoms and suicidality. Given that women suffer from major depression at twice the rate of men, it is important to understand how ketamine works in the female brain. This review explores three themes. First, it examines our current understanding of the etiology of depression in women. ...

Article GUID: 35115970


Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database

Author(s): Rurak GM; Simard S; Freitas-Andrade M; Lacoste B; Charih F; Van Geel A; Stead J; Woodside B; Green JR; Coppola G; Salmaso N;

Astroglial cells are key players in the development and maintenance of neurons and neuronal networks. Astroglia express steroid hormone receptors and show rapid responses to hormonal manipulations. However, despite important sex differences in the cortex and hippocampus, few studies have examined ...

Article GUID: 35108542


Search for magnetic monopoles produced via the Schwinger mechanism

Author(s): Acharya B; Alexandre J; Benes P; Bergmann B; Bertolucci S; Bevan A; Branzas H; Burian P; Campbell M; Cho YM; de Montigny M; De Roeck A; Ellis JR; Sawy ME; Fairbairn M; Felea D; Frank M; Gould O; Hays J; Hirt AM; Ho DL; Hung PQ; Janecek J ...

Electrically charged particles can be created by the decay of strong enough electric fields, a phenomenon known as the Schwinger mechanism1. By electromagnetic duality, a sufficiently strong magnetic field would similarly produce magnetic monopoles, if they exist2. Magnetic monopoles are hypothet ...

Article GUID: 35110756


Decision-first modeling should guide decision making for emerging risks

Author(s): Morgan K; Collier ZA; Gilmore E; Schmitt K;

An emerging risk is characterized by scant published data, rapidly changing information, and an absence of existing models that can be directly used for prediction. Analysis may be further complicated by quickly evolving decision-maker priorities and the potential need to make decisions quickly as new information comes available. To provide a forum to dis ...

Article GUID: 35104915


The Algorithms of Mindfulness

Author(s): Johannes Bruder

This paper analyzes notions and models of optimized cognition emerging at the intersections of psychology, neuroscience, and computing. What I somewhat polemically call the algorithms of mindfulness describes an ideal that determines algorithmic techniques of the self, geared at emotional resilience and creative cognition. A reframing of rest, exemplified ...

Article GUID: 35103028


Conflict Resolution and Emotional Expression in Sibling and Mother-Adolescent Dyads: Within-Family and Across-Context Similarities

Author(s): Ferrar SJ; Stack DM; Baldassarre KS; Orsini A; Serbin LA;

Early adolescents (aged 12-15) were observed during dyadic conflict discussions with their siblings (n = 23) and mothers (n = 32) in their homes. The verbal conflict behaviors and affect of family members were coded continuously. Sequential analyses identified temporal associations between individuals' affect and their own and their partners' verb ...

Article GUID: 35103031


Disturbance cues function as a background risk cue but not as an associative learning cue in tadpoles

Author(s): Rivera-Hernández IAE; Crane AL; Pollock MS; Ferrari MCO;

Chemical information has an important role in the sensory ecology of aquatic species. For aquatic prey, chemical cues are a vital source of information related to predator avoidance and risk assessment. For instance, alarm cues are released by prey that have been injured by predators. In addition to providing accurate information about current risk, repea ...

Article GUID: 35099624


Development of the Japanese Version of the State Self-Compassion Scale (SSCS-J)

Author(s): Miyagawa Y; Tóth-Király I; Knox MC; Taniguchi J; Niiya Y;

Research in the U.S. developed and validated the State Self-Compassion Scale (SSCS), which measures self-compassionate reactions toward a specific negative event. The current study is aimed at developing the Japanese version of the State Self-Compassion Scale (SSCS-J) and extending previous findings in the U.S. by showing measurement invariance across sex ...

Article GUID: 35095662


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