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Metabolomics 2022 workshop report: state of QA/QC best practices in LC-MS-based untargeted metabolomics, informed through mQACC community engagement initiatives

Author(s): Dunn WB; Kuligowski J; Lewis M; Mosley JD; Schock T; Ulmer Holland C; Zanetti KA; Vuckovic D;

Introduction: The Metabolomics Quality Assurance and Quality Control Consortium (mQACC) organized a workshop during the Metabolomics 2022 conference. Objectives: The goal of the workshop was to disseminate recent findings from mQACC community-engagement efforts and to solicit feedback about a li ...

Article GUID: 37940740


Increased brain cholinergic innervation in isolated REM sleep behaviour disorder from prodromal multiple system atrophy

Author(s): Wickens RH; Postuma RB; de Villers-Sidani É; Pelletier A; Blinder S; Gagnon JF; Soucy JP; Montplaisir J; Bedard MA;

No abstract available

Article GUID: 37939636


Development and performance assessment of a new opensource Bayesian inference R platform for building energy model calibration

Author(s): Hou D; Zhan D; Wang L; Hassan IG; Sezer N;

Many factors contribute to the inherent uncertainty of energy consumption modeling in buildings. It is essential to perform a calibration and sensitivity analysis in order to manage these uncertainties. Despite the availability of several calibration methods, they are often deterministic and lack quantified uncertainties. Moreover, the selection of parame ...

Article GUID: 37936825


Nonlinear dynamic modeling and model-based AI-driven control of a magnetoactive soft continuum robot in a fluidic environment

Author(s): Moezi SA; Sedaghati R; Rakheja S;

In recent years, magnetoactive soft continuum robots (MSCRs) with multimodal locomotion capabilities have emerged for various biomedical applications. Developments in nonlinear dynamic models and effective control methods for MSCRs are deemed vital not only to gain a better understanding of their coupled magneto-mechanical behavior but also to accurately ...

Article GUID: 37932207


Background Checks: Disentangling Class, Race, and Gender in CRPG Character Creators

Author(s): Iantorno M; Consalvo M;

Character backgrounds are one of many elements players use to customize their protagonists in fantasy computer role-playing games. By documenting the narrative trappings, mechanical benefits, and hierarchical availability of character backgrounds in Arcanum: Of Steamworks and Magick Obscura (2001) and Dragon Age: Origins (2009), this paper considers how r ...

Article GUID: 37928454


Electroconductive Collagen-Carbon Nanodots Nanocomposite Elicits Neurite Outgrowth, Supports Neurogenic Differentiation and Accelerates Electrophysiological Maturation of Neural Progenitor Spheroids

Author(s): Lomboni DJ; Ozgun A; de Medeiros TV; Staines W; Naccache R; Woulfe J; Variola F;

Neuronal disorders are characterized by the loss of functional neurons and disrupted neuroanatomical connectivity, severely impacting the quality of life of patients. This study investigates a novel electroconductive nanocomposite consisting of glycine-derived carbon nanodots (GlyCNDs) incorporated into a collagen matrix and validates its beneficial physi ...

Article GUID: 37922888


Medical Cannabis Use Among Canadian Veterans and Non-Veterans: A National Survey

Author(s): Valikhanova G; Kato Y; Fitzcharles MA; Ware M; Da Costa D; Lowensteyn I; Cheung HS; Grover S;

Background: Medical cannabis (MC) is used by Canadian Veterans to manage a wide range of health issues. However, there is little information comparing the reasons for MC use and its perceived effectiveness between Veterans and non-Veterans. Objects: We compared MC use among a convenience sample ...

Article GUID: 37920683


Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections

Author(s): Feng Y; Lu H; Whiteway M; Jiang Y;

Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) caused by Candida species. However, the mechanisms of FLC tolerance in Candida species remain to be fully ...

Article GUID: 37918789


Striking a balance: triage and crisis intervention models within the pediatric emergency room

Author(s): Laporte N; Hechtman L; Rousseau C; Greenfield B;

No abstract available

Article GUID: 37920538


Bayesian workflow for the investigation of hierarchical classification models from tau-PET and structural MRI data across the Alzheimer's disease spectrum

Author(s): Belasso CJ; Cai Z; Bezgin G; Pascoal T; Stevenson J; Rahmouni N; Tissot C; Lussier F; Rosa-Neto P; Soucy JP; Rivaz H; Benali H;

Background: Alzheimer's disease (AD) diagnosis in its early stages remains difficult with current diagnostic approaches. Though tau neurofibrillary tangles (NFTs) generally follow the stereotypical pattern described by the Braak staging scheme, the network degeneration hypothesis (NDH) has su ...

Article GUID: 37920382


Solar neighborhoods: the impact of urban layout on a large-scale solar strategies application

Author(s): Singh K; Hachem-Vermette C; D' Almeida R;

The article addresses the challenges of evaluating energy performance in different neighborhood settings under various energy efficiency measures and proposes a methodology for selecting appropriate solar strategies on a neighborhood scale. The study selects five representative neighborhoods from various climatic zones with different building and street l ...

Article GUID: 37914754


Actovegin improves skeletal muscle mitochondrial respiration and functional aerobic capacity in a type 1 diabetic male murine model

Author(s): Kosik B; Larsen S; Bergdahl A;

Insulin deficiency in type 1 diabetes (T1D) leads to an impairment of glucose metabolism and mitochondrial function. Actovegin is a hemodialysate of calf blood, which has been shown to enhance glucose uptake and cell metabolism in healthy human skeletal muscle. The objectives of this study were to determine the effects of Actovegin on skeletal muscle mito ...

Article GUID: 37913525


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