Author(s): Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ;
Background: Alzheimer's disease (AD) is thought to result from a complex cascade of events involving several pathological processes. Recent studies have reported alterations in white matter (WM) microstructure in the early phase of AD, but WM remains understudied. We used a multivariate appro ...
Article GUID: 39782998
Author(s): Soucy JP; Belasso CJ; Cai Z; Bezgin G; Stevenson J; Rahmouni N; Tissot C; Lussier FZ; Rosa-Neto P; Rivaz HJ; Benali H;
Background: Tau aggregates in Alzheimer's disease (AD) induce loss of synapses and neurons, leading to cognitive impairment. Predicting tau and neurodegeneration temporal evolution could be used for prognostication and for assessing results of therapeutic trials. Tau PET and MRI volumetry are ...
Article GUID: 39784152
Author(s): Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ;
Background: Alzheimer's disease (AD) is thought to result from a complex cascade of events involving several pathological processes. Recent studies have reported alterations in white matter (WM) microstructure in the early phase of AD, but WM remains understudied. We used a multivariate appro ...
Article GUID: 39785351
Author(s): Grant N; Phillips N;
Background: Hearing loss (HL) is a risk factor for dementia that is prevalent in older adults. Altered brain connectivity is present in individuals with HL, individuals with subjective cognitive decline (SCD), and individuals with mild cognitive impairment (MCI). In individuals with HL, altered brain connectivity has been associated with impaired scores o ...
Article GUID: 39785420
Author(s): Cassandre Vielle
Through the lens of preclinical research on substance use disorders (SUD), I propose a reflection aimed at re-evaluating animal models in neuroscience, with a focus on ecological relevance. While rodent models have provided valuable insights into the neurobiology of SUD, the field currently faces a validation crisis, with findings often failing to transla ...
Article GUID: 39777969
Author(s): Rehan S; Phillips NA;
Psychosocial function is associated with cognitive performance cross-sectionally and cognitive decline over time. Using data from the COMPASS-ND study, we examined associations between psychosocial and cognitive function in 126 individuals with mild cognitive impairment, an at-risk group for Alzheimer's disease (AD). Psychosocial function was measured ...
Article GUID: 39773214
Author(s): Romkey ID; Matthews T; Foster N; Dalla Bella S; Penhune VB;
In cognitive science, the sensation of "groove" has been defined as the pleasurable urge to move to music. When listeners rate rhythmic stimuli on derived pleasure and urge to move, ratings on these dimensions are highly correlated. However, recent behavioural and brain imaging work has shown that these two components may be separable. To examine this pot ...
Article GUID: 39774498
Author(s): Leite ML; Comeau P; Zaghwan A; Shen Y; Manso AP;
Objectives: This study aimed to assess the potential of experimental dental resins containing ZnO nanoparticles (ZnO-NPs) for antimicrobial photodynamic therapy (aPDT) as a functional tool for the modulation of cariogenic biofilm in long-term. Methods: Minimum inhibitory and bactericidal concentrations (MIC/MBC) of ZnO-NPs against Streptococcus mutans we ...
Article GUID: 39765362
Author(s): Gao Z; Chen X; Xu J; Yu R; Zhang H; Yang J;
Drowsy driving is a leading cause of commercial vehicle traffic crashes. The trend is to train fatigue detection models using deep neural networks on driver video data, but challenges remain in coarse and incomplete high-level feature extraction and network architecture optimization. This paper pioneers the use of the CLIP (Contrastive Language-Image Pre- ...
Article GUID: 39771685
Author(s): Lambert S; Moodie EEM; McCusker J; Lokhorst M; Harris C; Langmuir T; Belzile E; Laizner AM; Brahim LO; Wasserman S; Chehayeb S; Vickers M; Duncan L; Esplen MJ; Maheu C; Howell D; de Raad M;
Background: Self-directed interventions are cost-effective for patients with cancer and their family caregivers, but barriers to use can compromise adherence and efficacy. Aim: Pilot a Sequential Multiple Assignment Randomized Trial (SMART) to develop a time-varying dyadic self-management interv ...
Article GUID: 39763142
Author(s): Heidl AJ; Gierc M; Saputra S; Waliwitiya T; Puterman E; Cohen TR;
It is unknown if children and youth who live in rural or "less rural" locations who enroll in the provincially funded Generation Health Clinic (British Columbia, Canada), a family-based lifestyle program for weight management, present with different health behaviors at baseline. Thus, we assessed sociodemographic and health behavior (diet, physical activi ...
Article GUID: 39761009
Author(s): Corran C; Norman P; O' Connor RM;
Studies have shown that those high in anxiety were at increased risk for alcohol use during the COVID-19 pandemic. Tension reduction theory points to anxiety sensitivity (AS) as a potential risk factor. Drinking to cope may further increase this risk. During the pandemic, those high in AS may have experienced increased stress and drank to cope, which may ...
Article GUID: 39761074
