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A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

Author(s): Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y;

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy to avoid FLC resistance and eliminate the ...

Article GUID: 36475771


Practical fixed-time trajectory tracking control of constrained wheeled mobile robots with kinematic disturbances

Author(s): Lu Q; Chen J; Wang Q; Zhang D; Sun M; Su CY;

This paper addresses the problem of practical fixed-time trajectory tracking for wheeled mobile robots (WMRs) subject to kinematic disturbances and input saturation. Firstly, considering the under-actuated characteristics of the WMR systems, the WMR model under kinematic disturbances is transformed into a two-input two-output interference system by using ...

Article GUID: 35039151


The effect of step-feeding distribution ratio on high concentration perchlorate removal performance in ABR system with heterotrophic combined sulfur autotrophic process.

Author(s): Li H, Li K, Guo J, Chen Z, Han Y, Song Y, Lu C, Hou Y, Zhang D, Zhang Y

In a lab-scale anaerobic baffled reactor (ABR) with eight compartments, the heterotrophic and sulfur autotrophic processes were combined to remove perchlorate. And then, the step-feeding distribution ratio of the heterotrophic perchlorate reduction unit (HPR unit) was optimized to achieve efficient removal of high concentration perchlorate. Under the opti ...

Article GUID: 33485237


Chemogenomic Profiling of the Fungal Pathogen Candida albicans.

Author(s): Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M

Antimicrob Agents Chemother. 2018 02;62(2): Authors: Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M

Article GUID: 29203491


Erratum for Chen et al., "Chemogenomic Profiling of the Fungal Pathogen Candida albicans".

Author(s): Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M

Antimicrob Agents Chemother. 2018 04;62(4): Authors: Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M PMID: 29588354 [PubMed]

Article GUID: 29588354


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